Results 121 to 130 of about 13,203,537 (398)

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
wiley   +1 more source

Safety management of a complex R and D ground operating system [PDF]

A perspective on safety program management was developed for a complex R&D operating system, such as the NASA-Lewis Research Center. Using a systems approach, hazardous operations are subjected to third-party reviews by designated-area safety committees ...
Connors, J. F., Maurer, R. A.
core   +1 more source

The Influence of Occupational Driver Stress on Work-related Road Safety: An Exploratory Review [PDF]

, 2007
Research has identified a number of stressors that could impact on the occupational driver by increasing stress levels and, for some individuals, causing adverse behaviour and effects, for example, aggressive behaviour, fatigue, inattention/distraction ...
Davey, Jeremy, Freeman, James, Rowland, Bevan, Wishart, Darren   +3 more
core   +1 more source

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

Precision and Safety of an Intravascular Temperature Management System for Postcardiac Arrest Syndrome Patients: A Multicenter Clinical Trial (COOL-ARREST JP) [PDF]

, 2020
Tsuyoshi Maekawa, Kotaro Kaneda, Ryosuke Tsuruta, Yasuhiro Kuroda, Ken Nagao, Hiroshi Rinka, Takeshi Takahashi, Hiroyuki Yokota, Shinichi Shirai, Mamoru Hase, Joji Kotani, Shigeatsu Endo, Katsutoshi Tanno, Noriaki Kokubun, Shuji Uemura, Jun‐ichi Nishida, Hisashi Fumiya, Eiji Sakawaki, Katsutoshi Terui, Tomohiro Takahashi, Chikahiko Hida, Chiaki Onodera, Akira Fuse, Tomohiko Masuno, Hideyoshi Onda, Hironori Ishii, Masato Miyauchi, F Kin, Atsuko Tsujii, Takeshi Suzuki, Masanori Arai, Jun Hagiwara, Takeshi Tsukamoto, Keiji Tanaka, Koichi Akutsu, Takeshi Yamamoto, Yusuke Hosokawa, Hiroshige Murata, Mitsunobu Kitamura, Hideki Miyaji, Hidekazu Kawanaka, T Hashizume, Shoji Yokobori, Isanori Miyaichi, Hideki Arimoto, Akihiro Fuke, Junichi Ishikawa, Takaya Morooka, Daisuke Arashi, Y Hamanaka, Ken Morimoto, Junpei Okawa, Taneaki Shigemitsu, Kenya Kawakita, Yuko Abe, Natsuyo Shinohara, Shuichi Okubo, Kazutaka Kiritsume, Hideyuki Hamatani, Koshiro Takano, Yasutaka Oda, Yoshikatsu Kawamura, Motoki Fujita, Takashi Nakahara, Yasutaka Koga, Yasuaki Ogino, Shinya Fukuda, Ichiko Mizuguchi, Mari Otsuji, Takefumi Yagi, Takashi Miyauchi, Ryou Tanaka, Masaki Toya, Tadashi Kaneko, Masashi Iwabuchi, Kenji Ando, Junichi Shimotakahara, Masahiro Harada, Toshihiro Sakurai, Maki Kitada, Shu Yamada, Kohei Karino, Tadashi Era, Kimio Kikushima, Kazuhiro Watanabe, Shingo Furuya, Kiyoshi Iida, Mitsunobu Enomoto, Masaaki Matsumoto, T Soga, H Hirose, Masakazu Matsuzaki, Tsutomu Kobari, Koichiro Kazeto, Kei Nishikawa, Atsunori Hashimoto, Takahiro Ueda, Takaaki Osako, Taihei Yamada, Kenichi Matsuda   +99 more
openalex   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

The new challenges of the manufacturing industry applying the norm ISO 45001:2018 [PDF]

, 2019
The present work reflects the impact that the manufacturing industries must solve in the application of the ISO 45001: 2018 Standard on Occupational Health and Safety Management Systems. In such, a globalized market where human and material assets must
Cano-Iglesias, Maria Jose, Cañero, Juan Miguel, Solano-Martos, Jose Francisco   +2 more
core  

Influence of Transformational and Transactional Leadership Style toward Food Safety Management System ISO 22000:2018 Performance of Food Industry in Pati Central Java

Inovbiz: Jurnal Inovasi Bisnis, 2019
The purpose of this study is to analyze the influence of transformational and transactional leadership styles to the performance of the implementation of a food safety management system ISO 22000: 2018 at PT.
A. Purwanto, Masduki Asbari, Priyono Budi Santoso   +2 more
semanticscholar   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Risk classification assessment and early warning of large deformation of soft rock in tunnels based on CNN-LSTM model

Scientific Reports
Tunnels in the Western Plateau region of China often face numerous problems of high ground stress, as well as highly fractured and weak rock masses in deep sections of the tunnel, which results in an increased risk of large soft rock deformation in ...
Xianmeng Zhang, Wang Minghao, Dan Feng, Wang Jingchun   +3 more
doaj   +1 more source