Results 81 to 90 of about 25,560,690 (288)

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

open access: yesAdvanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai   +9 more
wiley   +1 more source

Evaluating the Reporting and Safety Culture of an Airline According to Patankar and Sabin's Safety Culture Pyramid

open access: yesInternational Journal of Aviation, Aeronautics, and Aerospace
As a result of the literature review, it is seen that the safety management system in airline businesses is mostly evaluated with Reason's just culture model. The fact that there is no research examining Patankar and Sabin's (2010) safety culture pyramid
Seda Mumlu Karanfil
doaj   +1 more source

MRO Cybersecurity SWOT

open access: yesInternational Journal of Aviation, Aeronautics, and Aerospace, 2019
This article intended to identify gaps in the safety management system (SMS) framework when it comes to dealing with cyber risks and hazards in the maintenance, repair, and overhaul (MRO) industry.
Danita Baghdasarin
doaj   +1 more source

Design-Based Safety: Is System Safety a Public Misconception?

open access: yes, 2019
Outside our professional fraternity of system safety practitioners, I am amazed at the “hocus-pocus” image of what system safety is. In lay terms, system safety needs to be explained as a learning process to identify unrecognized hazards at time of ...
MacCollum, David
core   +1 more source

System Safety in Organizational Safety Decision Making [PDF]

open access: yes, 2016
The two cardinal aspects of safety are intrinsic safety and its demonstration. A key element of demonstrating system safety is the organizational structure that is best placed to ensure and demonstrate that high standards of safety are clearly in place ...
Jones, Malcolm
core   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

open access: yesAdvanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal   +5 more
wiley   +1 more source

The Safety Management System (SMS) As A Tool for Building Safety Culture in Aviation: A Qualitative Research

open access: yesJournal of Aviation
Safety culture is conceptualized as the combination of beliefs, values, norms, attitudes, roles, and practices—both social and technical—within an organization, aimed at mitigating the exposure to adverse or hazardous conditions for both internal and external individuals.
Gizem Kartal, Gokben Bayramoğlu
openaire   +2 more sources

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

open access: yesAdvanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han   +16 more
wiley   +1 more source

Preserving Motor Features by Alternative Re‐Referencing to Remove Heart Artifact on the Stentrode

open access: yesAdvanced Science, EarlyView.
Endovascular brain‐computer interfaces record neural activity from within cerebrovasculature, at the expense of electrocardiogram contamination. Band‐limited independent component analysis separates this heart‐based artifact from task‐relevant neural activity in each frequency band, enabling the reconstruction of cleaner neural recordings without the ...
Ariel K. Feldman   +11 more
wiley   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

open access: yesAdvanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon   +27 more
wiley   +1 more source

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