Results 1 to 10 of about 4,495,861 (247)

Safety Profile of Niraparib as Maintenance Therapy for Ovarian Cancer: A Systematic Review and Meta-Analysis

Current Oncology, 2022
Background: Patients with epithelial ovarian cancer (EOC), treated with niraparib maintenance, present with haematological and gastrointestinal toxicities. Limited data exist on niraparib safety assessment. Objective: To evaluate niraparib safety profile,
Antonia Pagkali, Ioannis Mamais, Adamantios Michalinos, Aris P. Agouridis   +3 more
doaj   +3 more sources

Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation

Biomolecules, 2021
Imuno TF® is a nutritional supplement composed of isolated transfer factors (TF) from porcine spleen. It is composed of a specific mixture of molecules that impact functions of the biological systems and historically is linked to the immune system ...
Hudson Polonini, Any Elisa de Souza Schmidt Gonçalves, Eli Dijkers, Anderson de Oliveira Ferreira   +3 more
doaj   +3 more sources

An Overview of the Safety Profile and Clinical Impact of CDK4/6 Inhibitors in Breast Cancer—A Systematic Review of Randomized Phase II and III Clinical Trials

Biomolecules, 2023
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is) have transformed the treatment of hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2−) breast cancer over the last decade.
Ioana-Miruna Stanciu, Andreea Ioana Parosanu, Cornelia Nitipir   +2 more
doaj   +3 more sources

Hybrid Polyelectrolyte Nanocomplexes for Non-Viral Gene Delivery with Favorable Efficacy and Safety Profile

Pharmaceutics, 2022
The development of nanovectors for precise gene therapy is increasingly focusing on avoiding uncontrolled inflammation while still being able to effectively act on the target sites.
Gabriele Maiorano, Clara Guido, Annamaria Russo, Andrea Giglio, Loris Rizzello, Mariangela Testini, Barbara Cortese, Stefania D’Amone, Giuseppe Gigli, Ilaria Elena Palamà   +9 more
doaj   +3 more sources

Safety profile of India’s influenza vaccine in a large-scale corporate vaccination drive [PDF]

Human Vaccines & Immunotherapeutics
Seasonal influenza causes substantial morbidity, mortality, and productivity losses worldwide, and although annual vaccination is recommended for adults, coverage in India remains low; corporate vaccination drives may improve access and uptake among ...
Neeraj Khatuja, Ravi Aggarwal, Trayambak Dutta, Manish Mahajan   +3 more
doaj   +2 more sources

In Vitro Safety, Off-Target and Bioavailability Profile of the Antiviral Compound Silvestrol

Pharmaceuticals, 2022
We characterized the in vitro safety and bioavailability profile of silvestrol, a compound effective against various viruses, such as corona- and Ebolaviruses, with an EC50 value of about 5 nM.
Susanne Schiffmann, Sandra Gunne, Thomas Ulshöfer, Marina Henke, Luise A. Roser, Ann-Kathrin Schneider, Jindrich Cinatl, Dominique Thomas, Yannick Schreiber, Pia Viktoria Wagner, Arnold Grünweller, Michael J. Parnham   +11 more
doaj   +3 more sources

Technologically-Treated Polyclonal Affinity-Purified Antibodies to the Tumor Necrosis Factor-α, Brain Specific S-100 Protein and Histamine in Treatment of Functional Dyspepsia: Results of the Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2022
The aim of the study was to evaluate the efficacy and safety of Kolofort® (a complex medicine containing technologically processed forms of antibodies to S-100 protein, tumor necrosis factor-α and histamine) in the management of functional dyspepsia (FD)
Yu. O. Shulpekova, I. V. Maev, V. B. Grinevich, I. B. Khlynov, Yu. G. Shvarts, V. T. Ivashkin   +5 more
doaj   +1 more source

The validity of giving adjuvant capecitabine after standard anthracycline and/or taxanes based neo-/adjuvant chemotherapy in early triple-negative breast cancer patients: An Egyptian prospective multicentric phase III trial [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2022
Background: Triple-negative breast cancer (TNBC) is considered an aggressive breast cancer subtype despite giving standard therapies, these patients have high metastatic and relapse rates in addition to short survival.
Marwa Abdelgawad, loay Gertalla, Alia Attia, Ahmed Hefni, lobna Abdelaziz   +4 more
doaj   +1 more source

Effectiveness and Safety Profile of Dupilumab in Chronic Rhinosinusitis with Nasal Polyps: Real-Life Data in Tertiary Care

Pharmaceuticals, 2023
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a type 2 pattern of inflammation resulting in the production of some cytokines. Dupilumab radically changes the treatment of CRSwNP, but, considering its recent approval, it may be ...
Cosimo Galletti, Maria Antonietta Barbieri, Francesco Ciodaro, Francesco Freni, Francesco Galletti, Edoardo Spina, Bruno Galletti   +6 more
doaj   +1 more source

Treatment Response, Survival Benefit and Safety Profile of PD-1 Inhibitor Plus Apatinib Versus Apatinib Monotherapy in Advanced Colorectal Cancer Patients

Frontiers in Oncology, 2022
PurposeProgrammed cell death protein 1 (PD-1) inhibitor plus apatinib is reported to be a promising strategy for advanced cancers. Moreover, a PD-1 inhibitor or apatinib exerts a certain efficacy in advanced colorectal cancer (CRC), whereas their ...
Dengdeng Pan, Dengdeng Pan, Dongliang Liu, Lichuan Liang, Tongyi Shen, Chenzhang Shi, Huanlong Qin, Huanlong Qin   +7 more
doaj   +1 more source