Results 1 to 10 of about 6,997,232 (211)

Safety Profile of Niraparib as Maintenance Therapy for Ovarian Cancer: A Systematic Review and Meta-Analysis

open access: yesCurrent Oncology, 2022
Background: Patients with epithelial ovarian cancer (EOC), treated with niraparib maintenance, present with haematological and gastrointestinal toxicities. Limited data exist on niraparib safety assessment. Objective: To evaluate niraparib safety profile,
Antonia Pagkali   +3 more
doaj   +3 more sources

Safety profile of India’s influenza vaccine in a large-scale corporate vaccination drive [PDF]

open access: yesHuman Vaccines & Immunotherapeutics
Seasonal influenza causes substantial morbidity, mortality, and productivity losses worldwide, and although annual vaccination is recommended for adults, coverage in India remains low; corporate vaccination drives may improve access and uptake among ...
Neeraj Khatuja   +3 more
doaj   +2 more sources

An Overview of the Safety Profile and Clinical Impact of CDK4/6 Inhibitors in Breast Cancer—A Systematic Review of Randomized Phase II and III Clinical Trials

open access: yesBiomolecules, 2023
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is) have transformed the treatment of hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2−) breast cancer over the last decade.
Ioana-Miruna Stanciu   +2 more
doaj   +3 more sources

Characterization and Safety Profile of Transfer Factors Peptides, a Nutritional Supplement for Immune System Regulation

open access: yesBiomolecules, 2021
Imuno TF® is a nutritional supplement composed of isolated transfer factors (TF) from porcine spleen. It is composed of a specific mixture of molecules that impact functions of the biological systems and historically is linked to the immune system ...
Hudson Polonini   +3 more
doaj   +3 more sources

Hybrid Polyelectrolyte Nanocomplexes for Non-Viral Gene Delivery with Favorable Efficacy and Safety Profile

open access: yesPharmaceutics, 2022
The development of nanovectors for precise gene therapy is increasingly focusing on avoiding uncontrolled inflammation while still being able to effectively act on the target sites.
Gabriele Maiorano   +9 more
doaj   +3 more sources

In Vitro Safety, Off-Target and Bioavailability Profile of the Antiviral Compound Silvestrol

open access: yesPharmaceuticals, 2022
We characterized the in vitro safety and bioavailability profile of silvestrol, a compound effective against various viruses, such as corona- and Ebolaviruses, with an EC50 value of about 5 nM.
Susanne Schiffmann   +11 more
doaj   +3 more sources

Tapentadol: an overview of the safety profile

open access: yesJournal of pain research, 2019
Long-term opioid therapy may be associated with analgesic efficacy and also predictable adverse events, including cardiovascular and pulmonary events, gastrointestinal disorders, endocrinological harms, psychological problems, impairment of driving ...
E. Polati   +3 more
semanticscholar   +7 more sources

Safety profile of the interleukin-1 inhibitors anakinra and canakinumab in real-life clinical practice: a nationwide multicenter retrospective observational study

open access: yesClinical Rheumatology, 2018
A few studies have reported the safety profile of interleukin (IL)-1 blockers from real life. The aim of this study is to describe anakinra (ANA) and canakinumab (CAN) safety profile in children and adults, based on data from a real-life setting ...
Romina Gallizzi   +2 more
exaly   +2 more sources

Technologically-Treated Polyclonal Affinity-Purified Antibodies to the Tumor Necrosis Factor-α, Brain Specific S-100 Protein and Histamine in Treatment of Functional Dyspepsia: Results of the Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

open access: yesРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии, 2022
The aim of the study was to evaluate the efficacy and safety of Kolofort® (a complex medicine containing technologically processed forms of antibodies to S-100 protein, tumor necrosis factor-α and histamine) in the management of functional dyspepsia (FD)
Yu. O. Shulpekova   +5 more
doaj   +1 more source

The validity of giving adjuvant capecitabine after standard anthracycline and/or taxanes based neo-/adjuvant chemotherapy in early triple-negative breast cancer patients: An Egyptian prospective multicentric phase III trial [PDF]

open access: yesEgyptian Journal of Cancer and Biomedical Research, 2022
Background: Triple-negative breast cancer (TNBC) is considered an aggressive breast cancer subtype despite giving standard therapies, these patients have high metastatic and relapse rates in addition to short survival.
Marwa Abdelgawad   +4 more
doaj   +1 more source

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