Results 101 to 110 of about 4,495,861 (247)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Other title: Thirty Seventh Annual Industrial Safety and Health Conference; Other title: 37th annual Governor's safety & health conference : safety and health - everybody profits; Other title: Governor's Safety and Health Conference

, 1986
"Sponsored by the Kansas Department of Human Resources, American Society of Safety Engineers, Kansas Wichita Chapter, [and] Safety & Health Council of Western Missouri & Kansas, Inc."; "Ramada Inn Hotel, Topeka, Kansas, November 19-21, 1986."Registration
Industrial Safety and Health Conference (37th : 1986 : Topeka, Kan.)
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Safety Case Workshop [PDF]

, 2014
In January 2013, a two-day Safety Case Workshop was conducted in Huntsville, Alabama under the sponsorship of the SAE International G-48 System Safety Committee and A-P-T Research, Inc. (APT). Attendees from industry, government and academia participated,
McDermid, John, Hendrix, Barry, Delong, Tom, West, Dave, Dezfuli, Homayoon, Swallom, Don, Frost, John, Schmedake, Robert   +7 more
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Prevention of complications and risk factors in invasive treatment of knee osteoarthritis

Journal of Education, Health and Sport
Introduction. When conservative treatment of knee osteoarthritis is insufficiently effective, invasive therapeutic approaches are increasingly used, including genicular nerve radiofrequency ablation, intra-articular hyaluronic acid injection, and ...
Anatolii Gozhenko
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Other title: 38th Annual Governor's Safety & Health Conference : training - safety's foundation; Other title: Governor's Safety and Health Conference

, 1987
"Sponsored by the Kansas Department of Human Resources, American Society of Safety Engineers, Kansas Wichita Chapter, [and] Safety & Health Council of Western Missouri & Kansas, Inc."; "Ramada Inn Hotel, Topeka, Kansas, November 18-20, 1987."Registration
Industrial Safety and Health Conference (38th : 1987 : Topeka, Kan.)
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Design-Based Safety: The Evolution of Safety

, 2015
The word “safety” has a variety of meanings. It is a condition of being free from “accidents,” or any device for preventing an accident. The word “accident” means “unintended event,” and does not reveal that there is a cause created by a “hazard.” In ...
MacCollum, David
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The effect of pressurized intraperitoneal aerosolized chemotherapy on the surgical treatment outcomes of ovarian cancer with peritoneal carcinomatosis

Исследования и практика в медицине
The development of new local treatment methods of peritoneal carcinomatosis in ovarian cancer is an urgent task due to the fact that in most cases complete surgical cytoreduction is technically impossible, and systemic cytostatic therapy does not provide
A. S. Dzasochov, A. A. Kostin, V. L. Astashov, A. B. Turiev, A. D. Uskov, M. A. Andreeva   +5 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Predicting Safety Culture: The Roles of Employer, Operations Manager and Safety Professional

, 2013
[[abstract]]Introduction: This study explores predictive factors in safety culture. Method: In 2008, a sample 939 employees was drawn from 22 departments of a telecoms firm in five regions in central Taiwan.
Wu, Tsung-Chih; Lin, Chia-Hung; Shiau, Sen-Yu
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