Results 151 to 160 of about 2,284 (202)

Crystal structure, Hirshfeld surface and crystal void analysis of (1<i>Z</i>)-1-[(<i>E</i>)-2-(2<i>H</i>-1,3-benzodioxol-5-yl-methyl-idene)hydrazin-1-yl-idene]-1,2-di-hydro-phthalazine. [PDF]

Acta Crystallogr E Crystallogr Commun
Manvizhi M, Senthilkumar S, Selvanayagam S.   +2 more
europepmc   +1 more source

Safrole oxide inhibits angiogenesis by inducing apoptosis

Vascular Pharmacology, 2005
Our previous studies indicate that 3, 4-(methylenedioxy)-1-(2′, 3′-epoxypropyl)-benzene (safrole oxide), a newly synthesized compound, induces apoptosis in vascular endothelial cells (VECs) and A549 lung cancer cells.
Bao-Xiang Zhao, Junying Miao
exaly   +2 more sources

Thermal, photosynthesis and antibacterial studies of bioactive safrole derivative as precursor for natural flavor and fragrance [PDF]

Arabian Journal of Chemistry, 2014
Safrole [5-allylbenzo[d][1,3]dioxole] was subjected to photochemical oxidation reaction with hydrogen peroxide in the presence of sodium lamp to give the corresponding epoxy derivative [5-oxiranylmethylbenzo[1,3]dioxole.
Suzan Khayyat
exaly   +2 more sources

Safrole suppresses murine myelomonocytic leukemia WEHI-3 cellsin vivo, and stimulates macrophage phagocytosis and natural killer cell cytotoxicity in leukemic mice

Environmental Toxicology, 2013
[[abstract]]Many anticancer drugs are obtained from phytochemicals and natural products. However, some phytochemicals have mutagenic effects. Safrole, a component of Piper betle inflorescence, has been reported to be a carcinogen.
Jai-Sing Yang, Chi-Cheng Lu
exaly   +1 more source

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Metabolism of Safrole in the Rat

Acta Pharmacologica et Toxicologica, 1983
Abstract:The urinary metabolites ofsafrole(4‐allyl‐l,2‐methylenedioxybenzene)in the rat were identified using gas chromatographic — mass spectrometric methods. The amounts of the individual metabolites excreted were determined gas chromatographically. Metabolite excretion was 93% in 72 hrs and most of this material (86%) consisted of metabolites formed
J, Klungsøyr, R R, Scheline
openaire   +2 more sources

Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells

Bioorganic and Medicinal Chemistry Letters, 2006
Previously we found that 3,4-(methylenedioxy)-1-(2′,3′- epoxypropyl)-benzene (safrole oxide) induced a typical apoptosis in A549 human lung cancer cells.
Bao-Xiang Zhao, Junying Miao, Shangli Zhang   +2 more
exaly   +2 more sources

Toxic properties of compounds related to safrole

Toxicology and Applied Pharmacology, 1965
Abstract Dihydrosafrole on chronic feeding produced benign and malignant esophageal tumors. Safrole is a hepatic carcinogen. Liver changes produced by isosafrole, safrole, and dihydrosafrole were of the same general type and included hepatic cell enlargement, which was usually focal and resulted in the formation of nodules; adenomatoid hyperplasia ...
E C, HAGAN, P M, JENNER, W I, JONES, O G, FITZHUGH, E L, LONG, J G, BROUWER, W K, WEBB   +6 more
openaire   +2 more sources

Physiologically Based Biokinetic (PBBK) Modeling of Safrole Bioactivation and Detoxification in Humans as Compared With Rats

Toxicological Sciences, 2012
A physiologically based biokinetic (PBBK) model for the alkenylbenzene safrole in humans was developed based on in vitro- and in silico-derived kinetic parameters.
Erryana Martati, Ans Punt, Ivonne Rietjens   +2 more
exaly   +2 more sources

Myristicin, safrole, and fagaramide as phytosynergists of xanthotoxin

Journal of Chemical Ecology, 1989
The methylenedioxyphenyl-containing (MDP) inhibitors of mixed-function oxidase detoxification enzymes, myristicin, safrole, fagaramide, and isosafrole, occur with xanthotoxin or other toxic furanocoumarins in plants of the families Umbelliferae and Rutaceae. All four MDP compounds have a synergistic effect on the toxicity of xanthotoxin toHeliothis zea.
openaire   +2 more sources