Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa +17 more
wiley +1 more source
Fatal spinal cord compression in a horse with chronic actinobacterial cranial nuchal bursitis
Summary A 14‐year‐old warmblood gelding was managed for waxing and waning cranial nuchal bursitis for 2 years. Intensive medical and surgical management was not curative, and the patient was subjected to euthanasia after becoming acutely recumbent. Ante‐mortem and post‐mortem next generation sequencing of bursal tissue and post‐mortem conventional PCR ...
H. Mesch +4 more
wiley +1 more source
Oral <i>Prevotella</i> induces fat taste impairment, visceral lipid accumulation and insulin resistance by downregulating Hedgehog signaling in taste buds. [PDF]
Liu X +17 more
europepmc +1 more source
Sag Harbor School District and Sag Harbor Secretarial Association of the Teachers Association of Sag Harbor (2004) [PDF]
core +1 more source
Summary A 17‐year‐old Swiss Warmblood mare presented with signs of left‐sided facial nerve paralysis and was diagnosed with left‐sided temporohyoid osteoarthropathy (THO). A partial ceratohyoidectomy was performed in the standing, sedated mare to treat this condition.
J. Kuhlmann +5 more
wiley +1 more source
OPG-Producing B Cells and RANKL-Expressing T Cells Define Immune Signatures Predictive of Bone Metastases in Breast Cancer. [PDF]
Monteiro AC +12 more
europepmc +1 more source
Temporohyoid osteoarthropathy presenting as unilateral epistaxis in a mare
Summary An 18‐year‐old Selle Français mare presented with recurrent mild left‐sided epistaxis. Guttural pouch endoscopy revealed multiple focal mucosal erosions and congested vasculature overlying an enlarged left temporohyoid joint (THJ), and standing cone beam computed tomography (CBCT) confirmed moderate left‐sided temporohyoid osteoarthropathy (THO)
S. E. Sage +4 more
wiley +1 more source
Joint Adaptation of a Digital Mental Health Intervention for University Students: Inductive Qualitative Analysis. [PDF]
Dooley J, Alsaadi N, Watkins E.
europepmc +1 more source
High-fat diet disrupts a septal control on feeding to promote obesity in male mice. [PDF]
Jiang S +9 more
europepmc +1 more source

