Results 111 to 120 of about 673,928 (344)

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

open access: yesMolecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source

Kabir and Pedagogy: Teaching the Politics of Religion through the Hagiography of an Indian Saint

open access: yesReligions
This essay discusses the virtues of hagiology-driven teaching and the pedagogical value of the saint in the religious studies classroom, focusing on how a series of class assignments and activities centered on the Indian devotional saint Kabir function ...
Patton Burchett
doaj   +1 more source

Saint Sheryl

open access: yes, 2019
Critic of a “purely impure” philosophy of our age. Corporate diversityand one of its central figures and cornerstone texts : Sheryl Sandberg andLean In.
openaire   +2 more sources

L’esprit saint

open access: yes, 1984
Ce livre cherche à éclairer ce qui constitue la dimension fondamentale de toute existence croyante, tant individuelle que collective : l'Esprit Saint, entendu comme désignant non seulement l'objet de la foi, mais comme son opérateur, 'sujet" par excellence, qui constitue ceux qui le reçoivent en sujets croyants dans leur rapport filial à Dieu et ...
Laurentin, René   +4 more
openaire   +3 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

open access: yesMolecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan   +4 more
wiley   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

open access: yesMolecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

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