Summary Patients with relapsed or refractory acute myeloid leukaemia (r/r AML) harbouring FMS‐like tyrosine kinase 3 (FLT3) mutations generally have poor prognosis and limited treatment options. The second‐generation FLT3 inhibitor gilteritinib provides better disease control compared to standard relapse therapies and was approved based on two ...
Desiree Kunadt +55 more
wiley +1 more source
Long-read genome sequencing resolves a de novo complex 18q12.1q21.2 triplication causing partial tetrasomy and reveals its underlying mechanism. [PDF]
Redaelli S +13 more
europepmc +1 more source
Abstract Attention and vigilance are fundamental cognitive abilities that develop throughout childhood and adolescence and have been associated with cognitively demanding activities such as formal musical training. This cross‐sectional study examined whether individuals engaged in long‐term musical training show superior attention and vigilance ...
Rafael Román‐Caballero +4 more
wiley +1 more source
Lower Preoperative Skeletal Muscle Index in Patients with Pathological T4 Colorectal Cancer: An Exploratory Retrospective Cohort Study. [PDF]
Kiss BI +11 more
europepmc +1 more source
Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra +5 more
wiley +1 more source
Trial trustworthiness assessment: commentary on the Cochrane 2025 systematic review on calcium supplementation during pregnancy. [PDF]
Torloni MR, Cormick G, Atallah AN.
europepmc +1 more source
Review: Social media use and adolescent mental health – an umbrella review and power analysis
Background The relationship between social media use (SMU) and adolescent mental health continues to garner considerable attention, yet findings remain inconsistent and contradictory. This umbrella review aims to synthesize recent evidence on this topic and explore whether inconsistencies may be due to inadequate statistical power. Methods A systematic
Katrine B. Tølbøll
wiley +1 more source
Serving the living and the dead: An integrated approach to Copper Age ceramic production and cultural dynamics in Campania, Southern Italy. [PDF]
De Falco M +4 more
europepmc +1 more source
Background Neurodevelopmental disorders (NDDs), including attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), intellectual disability (ID), and specific learning disorders (SLD), frequently co‐occur with psychiatric conditions (e.g. anxiety, depression).
Kathryn Fortnum +4 more
wiley +1 more source

