Results 171 to 180 of about 705,935 (294)

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

open access: yesThe FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak   +10 more
wiley   +1 more source

Transcatheter Aortic Valve Replacement Within a Structured Secondary Prevention Framework in Cardiovascular Disease. [PDF]

open access: yesCureus
Valle Mena MJ   +5 more
europepmc   +1 more source

CHildren of the Cohort Study (CHOC): Exploring parenting desire among people living with HIV in Switzerland

open access: yesHIV Medicine, EarlyView.
Abstract Background Although HIV is now a chronic condition with an excellent life expectancy, some personal aspects affecting people living with HIV (PLWH), such as parenting desire, are relatively understudied. This study aimed to explore parenting desire among PLWH in Switzerland.
Clara Merlin   +76 more
wiley   +1 more source

Ischemic Stroke as the First Manifestation of Primary Antiphospholipid Syndrome in a Patient With a Recent Diagnosis of HIV: A Case Report. [PDF]

open access: yesCureus
Esparza Salazar F   +11 more
europepmc   +1 more source

An efficient variable neighborhood search approach for the facility location problem with the limited choice rule

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract One of the most common problems in the expansion of a company consists of deciding the most appropriate locations for their facilities. This decision problem, known as the facility location problem, has been studied from different perspectives, considering a number of different constraints.
Enrique García‐Galán   +2 more
wiley   +1 more source

A fast metaheuristic approach for the planar multiple obnoxious facility location problem

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract The multiple obnoxious facility location problem is one of the most studied problems in the literature of the obnoxious facility location problems family. In this work, we propose an alternative algorithmic approach for this problem, based on an efficient metaheuristic procedure over a discretization of the plane based on Voronoi diagrams ...
Sergio Salazar   +2 more
wiley   +1 more source

Corrigendum to 'Integrated genomic and proteomic analysis of the mouse-adapted <i>Staphylococcus aureus</i> strain JSNZ', Current Research in Microbial Sciences, Volume 9, 2025, 100489. [PDF]

open access: yesCurr Res Microb Sci
Wolfgramm H   +15 more
europepmc   +1 more source

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

open access: yesJournal of Clinical Periodontology, EarlyView.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo   +11 more
wiley   +1 more source

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