Results 51 to 60 of about 2,541,283 (307)

Criteria For Expanding The Sales Tax Base: Services and Exemptions [PDF]

, 2011
This brief focuses on issues associated with the sales tax base and discusses the criteria and factors that should be considered in deciding which services to add to the sales tax base and which sales tax exemptions to eliminate or ...
Carolyn Bourdeaux, David L. Sjoquist, Peter Bluestone   +2 more
core  

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

The specificity of the marketing distribution policy; diagnostic procedures in the enterprise [PDF]

, 2016
In the article stages of marketing distribution policy diagnostics are defined. At the first stage, it is proposed to analyse factors of enterprise internal and external environment (gathering information about general trends in the markets and factors ...
Illiashenko, Sergii, Syhyda, Liubov
core  

The urgency of lifelong learning : a study on the learning of Information and Communication Technologies in populations 50+ [PDF]

, 2017
O presente artigo visa abordar uma investigação de doutoramento realizada nas universidades seniores do distrito de Castelo Branco no ano letivo 2013/2014, que teve como principal objetivo identificar os fatores socioculturais que influenciam e ...
carreras, czaja, fernandes, fernández-ballesteros, fonseca, fonseca, garcia, gil, gil, gil, hazzlewood, jaeger, kachar, mariz, odebrecht, páscoa, páscoa, rebelo, sales, sei   +19 more
core   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

What a Difference a Law Makes: Online Gun Sales in States With and Without Background Checks [PDF]

, 2013
It is estimated that today there are about 4,000 websites dedicated to facilitating gun sales between private individuals. One of the largest of these sites -- Armslist.com -- essentially serves as an eHarmony or Craigslist for gun sales, connecting gun ...

core  

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

For Sale: Geography in Old Nubian Land Sales [PDF]

Dotawo: A Journal of Nubian Studies, 2019
In this article I want to focus on the way in which land property is described within the Makuritan kingdom, based on a grammatical analysis of Old Nubian land sales. I will argue that such descriptions are always relative in nature, referring to adjacent plots oriented from south to north on the banks of the Nile.
openaire   +3 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Magazine sales promotion : a dynamic response analysis [PDF]

, 2006
This paper studies the impact and effectiveness of a type of non-price promotion often used in the European periodical magazines industry to stimulate sales, in which a value pack is sold containing the magazine issue plus another product.
Esteban-Bravo, Mercedes, Múgica, Jose M., Vidal-Sanz, Jose M.   +2 more
core   +1 more source