Results 151 to 160 of about 54,661 (333)

Colo‐Protective Effects of Pentoxifylline Alone or in Combination With Mesalamine in Colitis Through Sphingosine Kinase 1/Sphingosine 1 Phosphate, and Zonula Occuldin 1 Pathways: New Molecular Approach

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Multiple signaling pathways have been implicated in the pathogenesis of ulcerative colitis (UC), including Sphingosine Kinase 1 (SPHK)/Sphingosine‐1‐Phosphate (S1P), AMP‐activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/NLR family pyrin domain‐containing 3 (NLRP3), zonula occludens‐1 (ZO‐1), and signal transducer and ...
Fatemah A. Alherz   +18 more
wiley   +1 more source

Management of type II Diabetes Mellitus [PDF]

open access: yes, 2002
There is currently no cure for diabetes mellitus (DM). Irrespective of whether type I or type II diabetes is treated, the overall goals of management and therapy are targeted towards patient well being and may be summarised as follows.peer ...
Tonna, Antonella
core  

The Ancient Drug Salicylate Indirectly Targets Fructose‐1,6‐Bisphosphatase to Suppress Liver Glucose Production in Diet‐Induced Obese Mice

open access: yesActa Physiologica, Volume 241, Issue 6, June 2025.
ABSTRACT Aims The benefit of salicylate in the treatment of diabetes has been recognized for over a century; however, challenging side effects have prevented widespread use. A better understanding of the relevant enzyme targets mediating its anti‐hyperglycaemic effect may lead to the development of novel therapies for diabetes.
Raid B. Nisr   +8 more
wiley   +1 more source

The use of topical diclofenac in the pain management of osteoarthritis of the knee [PDF]

open access: yes, 2006
Osteoarthritis (OA) is a common complaint that affects millions of people worldwide. As there is no cure for OA, drug treatment is the main form of management.
Banning, M
core  

Recruitment of Sugar Transport and Scent Volatile Genes for Prey Attraction in the Nectar Spoon of Heliamphora tatei

open access: yesEvolution &Development, Volume 27, Issue 2, June 2025.
Prey attraction is an integral component of the carnivorous syndrome, yet its molecular adaptations have remained largely unexplored. Our study utilized tissue‐specific transcriptomic data from the South American marsh pitcher plant, Heliamphora tatei, to explore the molecular and developmental basis of prey attraction.
Sukuan Liu, Stacey D. Smith
wiley   +1 more source

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