Results 161 to 170 of about 116,902 (337)

Nanocrystal Compressive Residual Stresses: A Strategy to Strengthen the Bony Spines of Osteocytic and Anosteocytic Fish

open access: yesAdvanced Science, Volume 12, Issue 20, May 29, 2025.
Advanced neoteleost fishbones, such as medaka, challenge bone adaptation strategies. While zebrafish bones contain osteocyte‐mediated porosity, medaka bones lack it, raising questions about alternative reinforcement mechanisms. Using advanced imaging, this study reveals higher residual compressive strains in medaka bone, suggesting an adaptation that ...
Andreia Silveira   +7 more
wiley   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

open access: yesAdvanced Science, Volume 12, Issue 20, May 29, 2025.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen   +16 more
wiley   +1 more source

Grains of Saliency: Optimizing Saliency-based Training of Biometric Attack Detection Models [PDF]

open access: yesarXiv
Incorporating human-perceptual intelligence into model training has shown to increase the generalization capability of models in several difficult biometric tasks, such as presentation attack detection (PAD) and detection of synthetic samples. After the initial collection phase, human visual saliency (e.g., eye-tracking data, or handwritten annotations)
arxiv  

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

open access: yesAdvanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao   +4 more
wiley   +1 more source

Data Augmentation via Latent Diffusion for Saliency Prediction [PDF]

open access: yesarXiv
Saliency prediction models are constrained by the limited diversity and quantity of labeled data. Standard data augmentation techniques such as rotating and cropping alter scene composition, affecting saliency. We propose a novel data augmentation method for deep saliency prediction that edits natural images while preserving the complexity and ...
arxiv  

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

open access: yesAdvanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui   +17 more
wiley   +1 more source

Copy Number Gains of VPS72 Drive De Novo Lipogenesis and Hepatocarcinogenesis via ATF3/mTORC1/SREBP1 Axis

open access: yesAdvanced Science, Volume 12, Issue 20, May 29, 2025.
VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. VPS72 modulates the epigenetic landscape of ATF3 promoter, such as H2A.Z acetylation reduction and DNA methylation increase, which results in ATF3 repression and subsequent activation of mTORC1.
Qinglin Zhang   +4 more
wiley   +1 more source

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