Results 51 to 60 of about 10,257 (261)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Visual Saliency Models for Text Detection in Real World. [PDF]
PLoS ONE, 2014 This paper evaluates the degree of saliency of texts in natural scenes using visual saliency models. A large scale scene image database with pixel level ground truth is created for this purpose.
Renwu Gao +4 more
doaj +1 more source
Saliency Mapping Enhanced by Structure Tensor [PDF]
Computational Intelligence and Neuroscience, 2015 We propose a novel efficient algorithm for computing visual saliency, which is based on the computation architecture of Itti model. As one of well-known bottom-up visual saliency models, Itti method evaluates three low-level features, color, intensity, and orientation, and then generates multiscale activation maps. Finally, a saliency map is aggregated
Zhiyong He, Xin Chen, Li-Ning Sun
openaire +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Adaptive Fusion for RGB-D Salient Object Detection
IEEE Access, 2019 RGB-D (red, green, blue, and depth) salient object detection aims to identify the most visually distinctive objects in a pair of color and depth images.
Ningning Wang, Xiaojin Gong
doaj +1 more source
Evaluating perceptual and semantic interpretability of saliency methods: A case study of melanoma
Applied AI Letters, 2022 In order to be useful, XAI explanations have to be faithful to the AI system they seek to elucidate and also interpretable to the people that engage with them.
Harshit Bokadia +4 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Benchmarking Perturbation-Based Saliency Maps for Explaining Atari Agents
Frontiers in Artificial Intelligence, 2022 One of the most prominent methods for explaining the behavior of Deep Reinforcement Learning (DRL) agents is the generation of saliency maps that show how much each pixel attributed to the agents' decision.
Tobias Huber +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Remote Sensing, 2017 Traditional saliency analysis models have made great advances in region of interest (ROI) extraction in natural scene images and videos. However, due to different imaging mechanisms and image features, those approaches are not quite appropriate for ...
Libao Zhang, Shiyi Wang
doaj +1 more source