Results 211 to 220 of about 2,900,627 (391)

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Subchondral physiology and vasculo-mechanical factors in load transmission and osteoarthritis

Bone & Joint Research, 2021
Michael C. Beverly, David W. Murray
doaj   +1 more source

Bovine Plasma Albumin in Buffered Saline Solution As a Diluent for Viruses [PDF]

, 1949
G. W. A. Dick, R. M. Taylor
openalex   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

In-situ Raman spectroscopic analysis of phase transition temperatures in silica interacting with water and NaCl solutions. [PDF]

Sci Rep
Pamula K, Pophali A, Gersappe D, Kim T.
europepmc   +1 more source

Conditions govering the Salinity Fluctuations of the Upper Layer of Sea Water found through Daily Observations at Mikomoto Is., Idu Peninsula

, 1940
N. Obara
openalex   +2 more sources

Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats

Advanced Biology, EarlyView.
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang, Biying Dong, Jie Chen, Zhenqiang Zhang, Weitong Zeng, Longxiong Liao, Xia Xiong, Xuejun Qin, Xianming Fan   +8 more
wiley   +1 more source

Combustion products of burn pit constituents induce more changes in asthmatic than non-asthmatic murine lungs. [PDF]

Part Fibre Toxicol
Belfield-Simpson L, Martin JR, McPeek MK, Livraghi-Butrico A, Dang H, Kim YH, Gilmour MI, Doerschuk CM.   +7 more
europepmc   +1 more source

Variation of the Surface Salinity duo to Rainfalls in Kominato Bay

, 1940
Masaharu IGARAST
openalex   +2 more sources