Results 61 to 70 of about 53,800 (258)

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

open access: yesAdvanced Science, EarlyView.
ABSTRACT Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...
Xiaoyan Tang   +8 more
wiley   +1 more source

Ion Superhighways in a Hierarchical Polymer‐Ceramic Membrane Enable Rapid and Selective Lithium Extraction

open access: yesAdvanced Science, EarlyView.
A flexible PDMS‐LATP polymer‐ceramic membrane creates lithium‐ion “superhighways” for rapid and selective extraction from complex brines. The amorphous PDMS matrix suppresses nonselective leakage and stabilizes the ceramic network, while LATP provides preferential Li+ conduction.
Xinxin Wei   +12 more
wiley   +1 more source

Isotopic Study on Saline Lakes in Antarctica

open access: yesAntarctic Record, 1977
In order to understand the origin of saline lakes in the southern Victoria Land, Soya Coast, and Vestfold Hills, the hydrogen and oxygen isotopic ratios of lake waters were measured. The relationship between the two isotopic ratios in these lakes shifted
Osamu MATSUBAYA   +2 more
doaj   +1 more source

Impacts of a Saline Lake and Its Salinity on Local Precipitation [PDF]

open access: yesAdvances in Meteorology, 2015
In the study, the weather research and forecasting model coupled with the community land model (WRF-CLM) is used to investigate impacts of the GSL and its salinity from October 2001 to April 2002. A salinity parameterization scheme is incorporated into the lake scheme of CLM.
openaire   +2 more sources

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

open access: yesAdvanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo   +10 more
wiley   +1 more source

Geochemical Study of the Formation Process for the Saline Lakes in the Dry Valleys, South Victoria Land, Antarctica

open access: yesAntarctic Record, 1977
A simple model is proposed for the present chemical composition of the saline lakes in the Dry Valleys. A diluted water of sea salt whose compositional ratio was that of sea water was concentrated by evaporation to the present chlorinity.
Shyu NAKAYA, Masakichi NISHIMURA
doaj   +1 more source

The soda lakes of Nhecolândia: A conservation opportunity for the Pantanal wetlands

open access: yesPerspectives in Ecology and Conservation, 2019
The Pantanal is the most conserved biome in Brazil and among the last wild refuges in South America, but intensification of agriculture and other land use changes present challenges for protecting this exceptionally biodiverse wetland ecosystem.
Renato L. Guerreiro   +6 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

open access: yesAdvanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl   +20 more
wiley   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu   +9 more
wiley   +1 more source

Limnology and plankton diversity of salt lakes from Transylvanian Basin (Romania): A review

open access: yesJournal of Limnology, 2017
In the present work, we review the current knowledge on genesis, limnology and biodiversity of salt lakes distributed around the inner contour of Eastern Carpathian arc (Transylvanian Basin, Central Romania).
Mircea Alexe   +10 more
doaj   +1 more source

Home - About - Disclaimer - Privacy