Results 41 to 50 of about 6,234,586 (309)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Mangrove trees growing in a very saline condition but not using seawater [PDF]
, 2008 Mangrove trees, which develop along tropical coasts, are known to use saline water uptake. In French Guiana, the high salinity condition is the result of seawater evaporation on mud banks formed from the Amazon sediment flumes. In the back mangrove a few
Muller, Etienne +2 more
core +1 more source
Biology, 2020 Carassius auratus gibelio is an omnivore favored for its flavor and is commonly used as a benthic species in traditional pond polyculture. This study investigated the effects of common aquaculture stressors, such as high ammonia, high nitrite, high pH ...
Zongli Yao +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Research and development progress report 705 [PDF]
, 1971 Report describing the MSF/VTEX Distillation Plants at the San Diego Test Facility of the Office of Saline Water for the purpose of advancing and developing the state of the art of flash distillation plants and thereby reducing the cost of seawater ...
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Scientific ReportsGymnocypris przewalskii is an endemic migratory fish in the high-altitude, saline-alkaline Lake Qinghai. This study investigated whether L-serine (Ser) acts as a chemical cue guiding its migration.
Huanhuan Wang +11 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Office of Saline Water Reports [PDF]
, 1961 Report issued by the Office of Saline Water over studies conducted on a thin film sea water distillation unit. As stated in the summary, "a General Electric Thin Film Sea Water Distillation Unit designed for marine application has been evaluated.
General Electric Company
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source