Results 41 to 50 of about 8,989 (214)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Tuning polyamide membrane chemistry for enhanced desalination using Boc-protected ethylenediamine and its in situ Boc-deprotection

npj Clean Water
The scarcity of freshwater resources, driven by rapid population growth and industrialization, underscores the urgent need for advanced desalination technologies.
Hilal Ahmad, Abdul Waheed, Fahad Ayesh Alharthi, Christopher Michael Fellows, Umair Baig, Isam H. Aljundi   +5 more
doaj   +1 more source

Soil Organic Matter and Bulk Density: Driving Factors in the Vegetation-Mediated Restoration of Coastal Saline Lands in North China

Agronomy
Coastal saline soils are an important soil resource that, when restored, can enhance arable land and preserve the natural ecology. With the aim of improving the use of coastal saline soils, we conducted a spot survey at Bohai coastal saline land to ...
Weiliu Li, Jingsong Li, Yujie Wu, Kai Guo, Xiaohui Feng, Xiaojing Liu   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Challenges and Perspectives on Photocatalytic Membrane Reactors for Volatile Organic Compounds Degradation and Nitrogen Oxides Treatment

Global Challenges
Air pollution is a pressing environmental and public health issue, with volatile organic compounds (VOCs) and nitrogen oxides (NOx) being among the most hazardous airborne pollutants.
Muhammad Hassnain, Asad Ali, Muhammad Rizwan Azhar, Abdulrahman Abutaleb, Muhammad Mubashir   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Nutritional and cooking quality superiority of black rice genotype BPT 2841 with enhanced lysine content

Scientific Reports
BPT Rice 2841 is a black rice variety developed through a three-way cross involving MTU 7029 (Swarna), IRGC 18,195 and MTU 1081. BPT Rice 2841 is a high-yielding, non-lodging, semi-dwarf black rice variety suitable for the Kharif season in the Krishna ...
B. Krishna Veni, D. Sandeep Raja, M. Tushara, Y. Suneetha, K. A. Mrudhula   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Poly-γ-glutamic acid improves soil structure to enhance seed cotton yield and fiber quality in arid saline regions

Industrial Crops and Products
Soil salinization has become a prominent global environmental challenge, posing a serious threat toward the irrigated farming systems. Poly-γ-glutamic Acid (γ-PGA) functions as a bio-degradable and eco-benign soil amendment, which is essential for ...
Mengjie Liu, Jiliang Zheng, Yue Wen, Feihu Yin, Tehseen Javed, Jinzhu Zhang, Zhenhua Wang   +6 more
doaj   +1 more source