Results 71 to 80 of about 6,234,586 (309)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

United States Office of Saline Water Report 277

, 1967
Report issued by the Office of Saline Water discussing the conceptual design of a 50 MGD water desalination plant. Numerous design concepts are presented, along with detailed descriptions and comparisons of the different designs.
Hunter, J. A., Sieder, Everett N., Tomalin, Paul G.   +2 more
core  

Saline-Water Resources of North Dakota [PDF]

, 1958
A description of the principal saline-water aquifers and surface-water bodies, with available ...
Langford, R. H., Robinove, C. J.
core  

Impacts of Saline Water Irrigation on Soil Respiration from Cotton Fields in the North China Plain

, 2023
Saline water irrigation has been widely used for crop production where agriculture is short of freshwater. However, information about the response of soil respiration to saline water irrigation is limited.
Caiyun Cao, Chunping Xu, Hongkai Dang, Yang Gao, Jie Pang, Junpeng Zhang, Jingsheng Sun, Abdoul Kader Mounkaila Hamani, Shuang Zhou, Guangshuai Wang   +9 more
core   +1 more source

Effect of Combined Application of Wood Vinegar Solution and Biochar on Saline Soil Properties and Cotton Stress Tolerance

Plants
Biomass pyrolysis by-products, such as biochar (BC) and wood vinegar (WV), are widely used as soil conditioners and efficiency enhancers in agriculture.
Liu Yang, Guangmu Tang, Wanli Xu, Yunshu Zhang, Songrui Ning, Pujia Yu, Jie Zhu, Qingsong Wu, Peng Yu   +8 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

CROP DENSITY AND IRRIGATION WITH SALINE WATER [PDF]

The economic implications of plant density for irrigation water use under saline conditions are investigated, utilizing the involved physical and biological relationships. The analysis considers a single crop and is applied to cotton data.
Feinerman, Eli
core  

A Method of Coupling Lucerne Quality with Meteorological Data to Evaluate the Suitability of Hay Harvest

Agronomy
The alfalfa harvest time is determined by the alfalfa growth stage and the weather factors at that time, which will affect the yield and quality of the alfalfa hay. Addressing issues like the lack of precise harvesting timing and underutilized production
Yao Li, Jin Xie, Huitao Liu, Lipu Han
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source