Results 51 to 60 of about 7,573 (281)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Application of salinity gradient power for brines disposal and energy utilisation

open access: yesDesalination and Water Treatment, 2009
Disposal of high saline brines is a common and important problem in many industrial plants. These waste streams may be generated in large volumes in many different industries. It is well known that these concentrated brines cannot be desalted by using the conventional desalination technologies due to two crucial factors which are; cost and reliability.
M. Ahmad, P. Williams
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Effect of Gaskets Geometry on the Performance of a Reverse Electrodialysis Cell

open access: yesEnergies, 2022
Salinity gradient energy (SGE) allows the difference in salt concentration in two volumes of water to be harnessed and transformed into clean energy. The most advanced SGE technology is reverse electrodialysis (RED) cells.
Elier Sandoval-Sánchez   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Improved Rectification and Osmotic Power in Polyelectrolyte-Filled Mesopores

open access: yesMicromachines, 2020
Ample studies have shown the use of nanofluidics in the ionic diode and osmotic power generation, but similar ionic devices performed with large-sized mesopores are still poorly understood.
Ding-Cheng Zheng, Li-Hsien Yeh
doaj   +1 more source

Reverse electrodialysis for salinity gradient power generation

open access: yesJournal of Membrane Science & Research, 2018
Salinity gradient energy, which is also known as Blue energy, is a renewable energy form that can be extracted from the mixing of two solutions with different salinities. About 80% of the current global electricity demand could potentially be covered by this energy source.
Güler, Enver, Nijmeijer, Kitty
openaire   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi   +8 more
wiley   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy