Results 141 to 150 of about 2,537 (305)

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Response of Fecal Bacteria and Fungi to Tannin‐Rich Diets in Sika Deer (Cervus nippon): Evidence from Both Feeding Experiments and Field Investigations

Integrative Zoology, EarlyView.
Feeding with tannin‐rich diets altered the fecal microbial composition and increased the relative abundance of tannin‐degrading microbes. We hypothesize that fecal bacteria and fungi may play important roles in helping herbivores adapt to tannin‐rich diets but respond to different tannin concentrations varies.
Di Zhu, Feng Wu, Peiying Wen, Haiyang Gao, Xiaoran Hao, Hongfang Wang   +5 more
wiley   +1 more source

Twenty years of shock wave research at the Institute for Surgical Research [PDF]

, 2002
Delius, Michael
core   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

Acta Ophthalmologica, EarlyView.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan   +2 more
wiley   +1 more source

Giant Asymptomatic Submandibular Sialolith: A Case Report Accompanied by Systematic Review. [PDF]

Clin Pract
Azevedo RG, Toro LF, Ganzaroli VF, Ifanger VJ, de Faria NA, de Rezende RU, da Conceição Francisquini J, Tessarin GWL.   +7 more
europepmc   +1 more source

Oral Health—Head and Neck Cancers: Addressing Confounding Through Negative Control and Quantitative Bias Analyses

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives While there are plausible biological explanations for the association between oral health and head and neck cancers (HNC), existing studies have yielded conflicting results. A key concern is that these associations are influenced by mediators, unmeasured risk factors, and biases. To address this, a negative control exposure was used
P. K. Elango, B. Nicolau, N. Farsi, A. V. Grant, M. C. Rousseau, S. Madathil   +5 more
wiley   +1 more source

Minimally Invasive Surgical Approach for Parotid Sialolith Removal. [PDF]

Cureus
Burman S, Das AK, Mallick D, Tamilmani S, Hembram S.   +4 more
europepmc   +1 more source