Results 181 to 190 of about 235,297 (357)

Differential Infectivity of the Lyme Disease SpirocheteBorrelia burgdorferiDerived fromIxodes scapularisSalivary Glands and Midgut [PDF]

open access: bronze, 2005
C. M. R. Lima   +6 more
openalex   +1 more source

Genetic Evidence Implicating Gut Microbiota and Circulating Cytokines in Sjögren's Syndrome

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Complex bidirectional causal relationships were found between gut microbiota abundance and Sjögren's syndrome (SS). Five circulating cytokines were shown to potentially affect SS, including MIG, IL‐5, IL‐1RA, IL‐2RA, and SCGF‐β, and SS was found to increase levels of two circulating cytokines, IL‐1β and IL‐5.
Yuchen Cai   +5 more
wiley   +1 more source

A Randomized Crossover Clinical Study to Assess the Effect of Oral Nicotine Pouches Used for Different Durations on Plasma Nicotine Pharmacokinetics in Healthy Oral Pouch Consumers

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Oral nicotine pouches (NPs), although addictive and not risk‐free, have potential application for a tobacco harm reduction approach. This study aims to further characterize their ability to deliver nicotine effectively. This randomized seven‐way crossover PK study in healthy oral pouch consumers evaluated 11 and 20 mg NPs used for 10, 20, and ...
David Azzopardi   +6 more
wiley   +1 more source

Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt   +3 more
wiley   +1 more source

Prospective Comparison of DWI‐Derived Virtual MR Elastography and Conventional MR Elastography in Metabolic Dysfunction‐Associated Steatotic Liver Disease and Healthy Volunteers

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Virtual MR elastography (VMRE) and MRE have been proposed for liver fibrosis staging in metabolic dysfunction‐associated steatotic liver disease (MASLD), but VMRE's diagnostic performance remains debated. Purpose To assess the inter‐visit and inter‐reader reproducibility of fat‐uncorrected and fat‐corrected diffusion‐weighted ...
Anton Volniansky   +13 more
wiley   +1 more source

Periodontitis in patients with severe erectile dysfunction undergoing penile prosthesis implantation: Clinical and immunohistochemical study

open access: yesJournal of Periodontology, EarlyView.
Abstract Background The relationship between periodontitis and erectile dysfunction (ED) has been poorly documented in Caucasian populations, particularly severe ED (SED) requiring penile prostheses. This study aimed to evaluate the association between periodontitis and SED in patients undergoing penile prosthesis implantation, and to identify clinical
Miguel Ángel Arrabal‐Polo   +8 more
wiley   +1 more source

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