Results 191 to 200 of about 79,043 (279)

EARLY HISTOCHEMICAL CHANGES IN IRRADIATED SALIVARY GLANDS AND LYMPH-NODES OF THE RAT. [PDF]

, 1964
GREENSPAN, JS, MELAMED, MR, PEARSE, AG
core  

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Spatial multi-omics profiling uncovers metabolic heterogeneity in Sjögren's syndrome and identifies PS(36:1) as a potential therapeutic target. [PDF]

J Transl Med
Shao Y, Cao N, Qian F, Wu D, Yang Y, Xia Y, Shen Z, Zhu L, Li J, Lu Y, Li C, Song Y, Xiao T, Lu T, Yang J, Lu J, Hu Z, Wang X, Xu Y, Zhang J.   +19 more
europepmc   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

A Case of Parvovirus B19 Infection Mimicking Mumps Virus Infection in a Healthy Adult. [PDF]

Eur J Case Rep Intern Med
Sedogawa H, Suwa Y, Nitta M, Sugito Y, Togawa Y, Tomita D.   +5 more
europepmc   +1 more source

Multidisciplinary Clinical Quality Indicators for Head and Neck Cancer: A Modified Delphi Study in Australia

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Monitoring delivery of cancer care is critical to improve outcomes in increasingly resource‐constrained settings. The aim of this study was to develop a priority set of multidisciplinary quality indicators (QIs) for benchmarking and monitoring the quality of care for head and neck cancer (HNC) in Australia.
Rebecca L. Venchiarutti, Ashleigh R. Sharman, Candice Donnelly, Nectarios Andrews, Martin Batstone, Sandeep Bhuta, Ruta Gupta, Claire Jeans, Jenny Lee, Eng H. Ooi, Mark Schifter, Puma Sundaresan, Swee T. Tan, Denyse Whelan, Takako (Eva) Yabe, Meiling Zhou, Carsten E. Palme, Jonathan R. Clark   +17 more
wiley   +1 more source

Association between sialoscintigraphy parameters and rheumatoid factor seropositivity in patients with suspected autoimmune glandular dysfunction. [PDF]

Clin Exp Med
Chuang MH, Wang YF, Chuang TL.
europepmc   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Complement contributes to ICI-triggered sialadenitis and predicts ICI efficacy. [PDF]

Cancer Immunol Immunother
Guan X, Liu M, Li A.
europepmc   +1 more source

Development and Validation of a Urinary Exosomal miRNA Diagnostic Panel for Early Detection of Esophageal Cancer

Cancer Science, EarlyView.
Using a machine learning–based approach in a multi‐institutional prospective cohort, we identified a robust miRNA signature that demonstrated high diagnostic accuracy for esophageal squamous cell carcinoma. Our 57‐miRNA panel achieved an AUC of 0.90 in the proof‐of‐concept cohort and 0.85 in an independent validation cohort, with a sensitivity of 84 ...
Tatsuro Murano, Hiroki Yamashita, Yuki Kano, Ken Takeuchi, Takayuki Amano, Takanobu Yoshimoto, Mayuko Otomo, Hisashi Fujiwara, Shin Namiki, Hiroki Yamaguchi, Yoriko Ando, Yumi Nishiyama, Mika Mizunuma, Yuki Ichikawa, Tomonori Yano   +14 more
wiley   +1 more source