Results 1 to 10 of about 2,258 (151)

Comparison of In Vitro and In Vivo Results Using the GastroDuo and the Salivary Tracer Technique: Immediate Release Dosage Forms under Fasting Conditions [PDF]

Pharmaceutics, 2019
The fasted state administration of immediate release (IR) dosage forms is often regarded as uncritical since physiological aspects seem to play a minor role for disintegration and drug release. However, recent in vivo studies in humans have highlighted that fasted state conditions are in fact highly dynamic.
Christian Schulze, Philipp Schick, Marie-Luise Kromrey   +2 more
exaly   +4 more sources

Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics

Pharmaceutics, 2023
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer ...
Theodora Tzakri, Lara Rehenbrock, Stefan Senekowitsch, Adrian Rump, Philipp Schick, Julius Krause, Marie-Luise Kromrey, Michael Grimm, Werner Weitschies   +8 more
doaj   +3 more sources

The Effect of Capsule-in-Capsule Combinations on In Vivo Disintegration in Human Volunteers: A Combined Imaging and Salivary Tracer Study

Pharmaceutics, 2021
Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge.
Adrian Rump, Franziska N. Weiss, Louisa Schulz, Marie-Luise Kromrey, Eberhard Scheuch, Mladen V. Tzvetkov, Tyler White, Shane Durkee, Kevin W. Judge, Vincent Jannin, Aouatef Bellamine, Werner Weitschies, Michael Grimm   +12 more
doaj   +3 more sources

Distribution of Sentinel Nodes in Non‐Parotid Salivary Gland Tumors—A Feasibility Study [PDF]

Cancer Reports
Background Salivary gland carcinomas are rare and heterogeneous malignancies, more common in the parotid gland but also in submandibular and minor salivary glands. Surgery, often combined with radiotherapy, is the main treatment.
Marcus Jansson, Rusana Bark, Alexandra Elliot, Lalle Hammarstedt‐Nordenvall, Caroline Gahm   +4 more
doaj   +2 more sources

A comparison of theacrine and methylliberine with caffeine as salivary markers for determining gastric emptying [PDF]

International Journal of Pharmaceutics: X
Gastric emptying is a critical determinant of the pharmacokinetics of orally administered drugs. A key limitation in studies using caffeine as a marker for gastric emptying is the requirement for prior caffeine abstinence, which can complicate study ...
Toni Wildgrube, Stefan Senekowitsch, Robin Krüger, Fabian Winter, Michael Grimm, Werner Weitschies, Philipp Schick   +6 more
doaj   +2 more sources

The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little [PDF]

International Journal of Pharmaceutics: X
Fluid co-administered with oral medication directly affects its behaviour. Often, people use fluids other than water when taking their medications. Capsules (mainly gelatine- and HPMC-based) are widely used solid oral dosage forms.
Dorota Sarwinska, Mathilde Leyh, Constantin Foja, Theodora Tzakri, Philipp Schick, Felix Morof, Julius Krause, James Mann, Richard Barker, Mladen Vassilev Tzvetkov, Werner Weitschies, Michael Grimm   +11 more
doaj   +2 more sources

Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

Pharmaceutics, 2022
Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation.
Stefan Senekowitsch, Philipp Schick, Bertil Abrahamsson, Patrick Augustijns, Thomas Gießmann, Hans Lennernäs, Christophe Matthys, Luca Marciani, Xavier Pepin, Alan Perkins, Maximilian Feldmüller, Sarah Sulaiman, Werner Weitschies, Clive G. Wilson, Maura Corsetti, Mirko Koziolek   +15 more
doaj   +1 more source

Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine

Pharmaceutics, 2023
Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs.
Stefan Senekowitsch, Constantin Foja, Toni Wildgrube, Philipp Schick, Christoph Rosenbaum, Julius Krause, Friederike Brokmann, Marie-Luise Kromrey, Stefan Engeli, Werner Weitschies, Michael Grimm   +10 more
doaj   +1 more source

Light sheet microscopy for single molecule tracking in living tissue. [PDF]

PLoS ONE, 2010
Single molecule observation in cells and tissue allows the analysis of physiological processes with molecular detail, but it still represents a major methodological challenge.
Jörg Gerhard Ritter, Roman Veith, Andreas Veenendaal, Jan Peter Siebrasse, Ulrich Kubitscheck   +4 more
doaj   +1 more source

Distribution of sentinel nodes from parotid tumors–A feasibility study

Cancer Medicine, 2023
Background Optimum management of the N0 neck is unresolved in parotid salivary gland cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis and its´ clinical use is increasing for head and neck tumors. The object of this
Lalle Hammarstedt‐Nordenvall, Rusana Bark, Alexandra Elliot, Mathias Von Beckerath, Caroline Gahm   +4 more
doaj   +1 more source