MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann +7 more
wiley +1 more source
Bridging Knowledge Systems and Perspectives to Inform Salmon Management and Research: A Kuskokwim River Case Study. [PDF]
Ecol EvolEsquible J +12 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso +3 more
wiley +1 more source
Decadal predictions of future habitat favourability of the European green crab (<i>Carcinus maenas</i>) on the Pacific Coast of North America. [PDF]
HydrobiologiaVillar DA +2 more
europepmc +1 more source
Dietary melatonin and its benefits on cardiovascular disease
British Journal of Pharmacology, EarlyView.Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits.
Karabo Tisane +2 more
wiley +1 more source
Per- and polyfluoroalkyl substances in commercially important marine species of fish and shellfish from Alaska and implications for human exposure. [PDF]
Toxicol RepFurin CG +4 more
europepmc +1 more source
Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease
Clinical Genetics, EarlyView.Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler +5 more
wiley +1 more source
Genetic Dissection of Growth Traits and Identification of Candidate Genes in Japanese Flounder (<i>Paralichthys olivaceus</i>) Using Single- and Multi-Trait Genome-Wide Association Analyses. [PDF]
Biology (Basel)Liang S +5 more
europepmc +1 more source
Computing Skinning Weights via Convex Duality
Computer Graphics Forum, EarlyView.We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley +1 more source
Rewilding the upper Klamath River Basin: rapid recolonization of Chinook salmon following the world's largest dam removal. [PDF]
Sci RepGoodman DH +11 more
europepmc +1 more source