Results 51 to 60 of about 4,215 (216)

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Results of salmon fishery in Magadan Region in 2023

Известия ТИНРО
Results of salmon fishery in 2023 are summarized for the main fishing districts of Magadan region. Data on the forecasted and actual catch of the species of pacific salmon and char (gen.
I. S. Golovanov, L. L. Khovanskaya, A. M. Korshukova, P. V. Khabarov, M. O. Ostrinsky, A. I. Barausov, A. V. Artyukhin, V. G. Zhukov   +7 more
doaj   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Understanding barriers, access, and management of marine mixed-stock fisheries in an era of reconciliation: Indigenous-led salmon monitoring in British Columbia

FACETS, 2021
Wild salmon are central to food security, cultural identity, and livelihoods of coastal Indigenous communities. Yet ongoing inequities in governance, declining fish populations, and mixed-stock ocean fisheries may pose challenges for equitable access ...
Jade R. Steel, William I. Atlas, Natalie C. Ban, Kyle Wilson, Jayda Wilson, William G. Housty, Jonathan W. Moore   +6 more
doaj   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Biological characteristics for the spawners of chum salmon Oncorhynchus keta caught in the Indigirka River in 2023

Известия ТИНРО
The main biological parameters of chum salmon Oncorhynchus keta are presented for the spawners caught during the research expedition conducted to the lower reaches of Indigirka in August-September 2023.
A. I. Nikiforov, L. N. Karpova
doaj   +1 more source

LIMITS AND OPERATIONAL EVALUATION OF THE SPAWNERS ESCAPEMENT TO THE SPAWNING GROUNDS AS TOOLS FOR PROSPECTIVE AND SHORT-TERM MANAGEMENT OF THE PACIFIC SALMON STOCKS IN THE RIVERS OF THE FAR-EASTERN FISHERIES BASIN

Известия ТИНРО, 2019
The major aspects of density regulation of the pacific salmons spawning are analyzed. Uncertainty of the ecological parameters considered traditionally as indicators of the salmons reproduction efficiency is discussed.
E. A. Shevlyakov, M. G. Feldman, V. I. Ostrovsky, V. V. Volobuev, A. M. Kaev, E. V. Golub, E. I. Barabanshchikov, I. S. Golovanov   +7 more
doaj   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Results of salmon fishery in the North Pacific Ocean and adjacent waters of the Arctic Ocean in 2024

Известия ТИНРО
Results of salmon fishery in 2024 are briefly presented for the Far East of Russia, Arctic, Japan, and northwestern North America.
S. L. Marchenko
doaj   +1 more source