Results 271 to 280 of about 125,644 (316)

A hybrid protein is a functional molecule to reduce the cytokine storm caused by excessively activated macrophages

Immunology &Cell Biology, Volume 103, Issue 4, Page 350-364, April 2025.
In this article, we have developed a hybrid protein, tentatively named human MIKO‐1 (hMIKO‐1). The messenger RNA expression of each proinflammatory cytokine was significantly suppressed by hMIKO‐1 despite a subsequent stimulation with lipopolysaccharide. hMIKO‐1 is a functional molecule that significantly attenuates the cytokine storm.
Masaki Ikemoto, Takuya Kotani, Kohki Okada, Shogo Matsuda, Tohru Takeuchi   +4 more
wiley   +1 more source

Colonic epithelial cell-specific TFEB activation: a key mechanism promoting anti-bacterial defense in response to Salmonella infection. [PDF]

Front Microbiol
Rao S, Huang P, Qian YY, Xia Y, Zhang H.
europepmc   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Antibiotic‐Induced Dysbiosis of the Gut Microbiota Shifts Host Tryptophan Metabolism and Increases the Susceptibility of Mice to Pulmonary Infection With Pseudomonas aeruginosa

Immunology, EarlyView.
Antibiotic‐induced dysbiosis of the gut microbiota shifts host tryptophan metabolism and impairs the innate immune response during Pseudomonas aeruginosa pulmonary infection. (A) Eubiosis: During eubiosis, the intestinal microbiota metabolises tryptophan into indole metabolites, which keeps tryptophan levels within normal serum concentrations. However,
Camila Bernardo de Brito, Raquel Duque do Nascimento Arifa, Rafael de Oliveira Bezerra, Carlos Eduardo Dias Igídio, Bárbara Maria de Amorim‐Santos, Anna Clara Paiva de Menezes Santos, Larissa Mendes Barbosa, João Paulo Pezzini Barbosa, Larissa Marcely Gomes Cassiano, Markus Kohlhoff, Micheli Fagundes, Rafaela Ribeiro Álvares Batista, Celso Martins Queiroz‐Junior, Alessandra M. Saliba, Juliana Divina Almeida Raposo, Fernão Castro Braga, Roney Santos Coimbra, Mauro Martins Teixeira, Caio Tavares Fagundes, Danielle G. Souza   +19 more
wiley   +1 more source

Dynamics of Salmonella Infection

, 2017
openaire   +4 more sources

Climate change effects in older people's health: A scoping review

Journal of Advanced Nursing, EarlyView.
Abstract Background Climate change has serious consequences for the morbidity and mortality of older adults. Objective To identify the effects of climate change on older people's health. Methods A scoping review was conducted following the Joanna Briggs Institute guidelines and the PRISMA‐ScR checklist.
Eva Mª Montoro‐Ramírez, Laura Parra‐Anguita, Carmen Álvarez‐Nieto, Gema Parra, Isabel Mª López‐Medina   +4 more
wiley   +1 more source

Effects of urban life on the gut microbiota and the susceptibility to avian malaria infection in a population of the house sparrow Passer domesticus

Journal of Avian Biology, Volume 2025, Issue 3, May 2025.
Life in urban areas may alter the gut microbiota and host physiology, leading to a higher susceptibility to pathogens. In contrast, specific members of the gut microbiota community have been shown to mitigate the intensity of malaria infection. House sparrows, living in close proximity to humans, are exposed to a unique environment with human‐shaped ...
Daliborka Stanković, Hugo J. Eira Pereira, Marko Raković, Stefan Skorić, Nayden Chakarov   +4 more
wiley   +1 more source

Salmonella infections in calves and piglets.

Annales de recherches veterinaires. Annals of veterinary research, 1983
Lintermans, P., Pohl, P.
openaire   +3 more sources