Results 231 to 240 of about 266,782 (353)

The genome and stage‐specific transcriptomes of the carrot weevil, Listronotus oregonensis, reveal adaptive mechanisms for host specialisation and symbiotic interactions

open access: yesInsect Molecular Biology, EarlyView.
Comprehensive genome and stage‐specific transcriptomes reveal 14,637 genes in Listronotus oregonensis, advancing genetic insights into a key agricultural pest. Compared with related species, L. oregonensis exhibits reduced chemoreceptor gene families but expanded detoxification gene clusters, reflecting its narrow host range and adaptability.
Dave T. Ste‐Croix   +2 more
wiley   +1 more source

Enhancing colistin efficacy against Salmonella infections with a quinazoline-based dual therapeutic strategy. [PDF]

open access: yesSci Rep
Lobertti CA   +8 more
europepmc   +1 more source

Non-typhoidal Salmonella infections across India: emergence of a neglected group of enteric pathogens. [PDF]

open access: yesJ Taibah Univ Med Sci, 2022
Kumar S   +4 more
europepmc   +1 more source

Microbe‐responsive human γδ T cells: the peculiar case of Staphylococcus aureus

open access: yesImmunology &Cell Biology, EarlyView.
Human Vγ9/Vδ2 T cells display a unique responsiveness towards microbial organisms producing the metabolite HMB‐PP. However, Staphylococcus aureus does not possess HMB‐PP but can induce activation, cytokine expression and proliferation of Vγ9/Vδ2 T cells regardless. We here discuss potential pathways, ligands and biological functions in this response to
Matthias Eberl   +3 more
wiley   +1 more source

HIV: is it now a thing of the past?

open access: yesInternal Medicine Journal, EarlyView.
Abstract Effective antiviral therapy for human immunodeficiency virus (HIV) has substantially reduced HIV‐associated morbidity and mortality for people living with HIV (PLWH). The use of antiviral therapies as prevention, most notably pre‐exposure prophylaxis (PrEP) as well as treatment as prevention (TasP), has significantly reduced the number of new ...
Jeffrey John Post
wiley   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

open access: yesImmunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu   +24 more
wiley   +1 more source

Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory

open access: yesImmunology, EarlyView.
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow‐derived innate cells, extensive transcriptomic analysis of haematopoietic progenitors, and challenge models of spirochetal infection, nonspecific inflammation, and model antigen ...
Samuel T. Pasco   +24 more
wiley   +1 more source

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