Results 61 to 70 of about 3,166,358 (335)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Dietary salt intake estimation by routine healthcare workers in an urban slum of Chandigarh: A feasibility study

International Journal of Noncommunicable Diseases, 2016
Context: Hypertension is an important modifiable risk factor for cardiovascular disease (CVD). From numerous studies, it was observed that excess dietary salt is responsible for 17-30% of high blood pressure and increases the risk of blood pressure ...
Sudip Bhattacharya, J S Thakur
doaj   +1 more source

Salt and Sensitivity [PDF]

Hypertension, 2013
See related article, p 499–505 Almost 110 years ago, Ambard and Beaujard1 were the first to systematically explore the association between salt intake and blood pressure. They start their article with the following statement (translated from French): “It seems to us that one can say that each individual who is able to retain chloride is, by that very
Abraham A. Kroon, Peter W. de Leeuw
openaire   +3 more sources

Which table salt to chose? [PDF]

, 2018
The link between salt consumption and hypertension has been the focus of many studies and clinical trials in the past few years. It is recommended that table salt intake does not exceed the maximum of 5g per day and yet most people find almost impossible
Brum, Sílvia, Carapeto, Cristina, Rocha, Maria João   +2 more
core   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Ultrasound-Assisted Marination: Role of Frequencies and Treatment Time on the Quality of Sodium-Reduced Poultry Meat

Foods, 2019
The objective of this study was to evaluate the influence of high-power ultrasound (US) to accelerate marination of chicken breast; the effect of ultrasonic frequencies and marination times were investigated on samples containing full sodium levels (FS ...
Elena S. Inguglia, Catherine M. Burgess, Joseph P. Kerry, Brijesh K. Tiwari   +3 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Bioactive Phenolate Salts: Thymol Salts

ChemMedChem, 2023
AbstractPhenolate salts of bioactive agents have been reported only scarcely. This is the first report on the formation and characterization of thymol phenolate salts as representatives of phenol‐containing bioactive molecules. Thymol has been used in medicine and agriculture for decades owing to its excellent therapeutic properties.
Pulikanti Guruprasad Reddy, Abraham J. Domb   +1 more
openaire   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]

, 2016
Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K., Mercer, John R., Salt, Ian P.   +2 more
core   +3 more sources