Results 41 to 50 of about 2,407,051 (386)

Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self–nonself discrimination

open access: yeseLife, 2021
Some RIG-I-like receptors (RLRs) discriminate viral and cellular dsRNA by their termini, and Drosophila melanogaster Dicer-2 (dmDcr-2) differentially processes dsRNA with blunt or 2 nucleotide 3’-overhanging termini. We investigated the transient kinetic
Raushan K Singh   +5 more
doaj   +1 more source

A Review on the Salt Bridge Between ASP177 and ARG163 of Wild-Type Rabbit Prion Protein

open access: yes, 2015
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species such as sheep and goats, cattle, deer, elks, humans and mice etc., but rabbits have a low susceptibility to be infected ...
Wang, Feng, Zhang, Jiapu
core   +2 more sources

N-Methylimidazole Promotes The Reaction Of Homophthalic Anhydride With Imines [PDF]

open access: yes, 2014
The addition of N-methylimidazole (NMI) to the reaction of homophthalic anhydride with imines such as pyridine-3-carboxaldehyde-N-trifluoroethylimine (9) reduces the amount of elimination byproduct and improves the yield of the formal cycloadduct ...
Aaron Levin   +25 more
core   +3 more sources

Demonstration of the stabilization of solar salt at 620 C with a semi-closed configuration in a 100 kg-scale

open access: yesHeliyon, 2023
Among the variety of energy storage techniques thermal energy storage (TES), based on molten salts, is already in use for the storage of heat in a gigawatt hour scale.
Sebastian Kunkel   +4 more
doaj   +1 more source

Phosphine-porphyrin conjugates : a thesis presented in partial fulfilment of the requirements for the degree of Masterate of Science in Chemistry at Massey University, New Zealand [PDF]

open access: yes, 2000
The research carried out in this thesis comprises an investigation into the synthesis and characterisation of a variety of complexed phosphine-aldehydes, complexed phosphinoporphyrins, and phosphinoferrocene conjugates.
Lun, David James
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Permeability and chemical analysis of aromatic polyamide based membranes exposed to sodium hypochlorite [PDF]

open access: yes, 2011
In this study, a cross-linked aromatic polyamide based reverse osmosis membrane was exposed to variable sodium hypochlorite ageing conditions (free chlorine concentration, solution pH) and the resulting evolutions of membrane surface chemical and ...
Aimar, Pierre   +4 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Using structure-function relationships to understand the mechanism of phenazine-mediated extracellular electron transfer in Escherichia coli

open access: yesiScience, 2021
Summary: Phenazines are redox-active nitrogen-containing heterocyclic compounds that can be produced by either bacteria or synthetic approaches. As an electron shuttles (mediators), phenazines are involved in several biological processes facilitating ...
Zayn Rhodes   +4 more
doaj   +1 more source

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