Results 51 to 60 of about 737,699 (340)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
A global model study of natural bromine sources and the effects on tropospheric chemistry using MOZART4 [PDF]
, 2018 Halogens in the atmosphere chemically destroy ozone. In the troposphere, bromine has higher ozone destruction efficiency than chlorine and is the halogen species with the widest geographical spread of natural sources. We investigate the relative strength
Rast, Sebastian, Sousa Santos, Gabriela
core
Salt-doped block copolymers: ion distribution, domain spacing and effective χ parameter [PDF]
, 2012 We develop a self-consistent field theory for salt-doped diblock copolymers, such as polyethylene oxide (PEO)–polystyrene with added lithium salts.
Nakamura, Issei, Wang, Zhen-Gang
core +1 more source
SeparationsRubidium and cesium are critical strategic elements, and their development and utilization are of great significance. In this study, a magnesium ammonium phosphate (MAP) adsorbent was prepared and characterized using scanning electron microscopy (SEM), X-
Haining Liu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
How does the local wind field control the aerosol distribution in coastal Dronning Maud Land? [PDF]
, 2011 Atmospheric circulation patterns and chemical concentrations in firn cores are highly related to each other. Atmospheric winds transport aerosols like sea salt and mineral dust over the globe and redistribute them.
Bigler, M. +4 more
core
Structural biology: a century-long journey into an unseen world [PDF]
, 2015 © Institute of Materials, Minerals and Mining 2015.When the first atomic structures of salt crystals were determined by the Braggs in 1912–1913, the analytical power of X-ray crystallography was immediately evident. Within a few decades the technique was
Curry, S
core +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
THE DEVELOPMENT OF ANDROID-BASED MOBILE LEARNING MEDIA AS CHEMISTRY LEARNING FOR SENIOR HIGH SCHOOL ON ACID BASE, BUFFER SOLUTION, AND SALT HYDROLYSIS [PDF]
, 2014 This research is a development research in chemistry education. The aims of this research were (1) to develop android-based mobile learning media for chemistry learning in senior high school on acid base, buffer solution, and salt hydrolysis, (2) to ...
Jaslin, Ikhsan +2 more
core