Results 61 to 70 of about 737,699 (340)

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

open access: yesMolecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella   +18 more
wiley   +1 more source

Activity of water in aqueous systems; A frequently neglected property [PDF]

open access: yes, 2005
In this critical review, the significance of the term ‘activity’ is examined in the context of the properties of aqueous solutions. The dependence of the activity of water(ℓ) at ambient pressure and 298.15 K on solute molality is examined for aqueous ...
Blandamer, Mike J.,   +3 more
core   +2 more sources

Chemistry of sea-salt particles and sea-salt fractionation in Antarctic region

open access: yesAntarctic Record, 2010
Observations of aerosol constituents and acidic gases were carried out at Syowa Station (1997-1998 and 2003-2006; JARE-38~ 39, and JARE-44~ 47) and Dome Fuji Station (1997, JARE-38).
Keiichiro Hara   +5 more
doaj   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

open access: yesFEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada   +3 more
wiley   +1 more source

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

open access: yesFEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo   +4 more
wiley   +1 more source

Exploring the scope of DBU-promoted amidations of 7-carboxymethyl-pterin [PDF]

open access: yes, 2020
Pteridines are an important heterocycle often used in the development of pharmaceutically relevant compounds, and in the field of supramolecular chemistry.
Bockman, Anna
core   +1 more source

A Pyrrole-Based Triazolium-Phane with Nh and Cationic Ch Donor Groups as a Receptor for Tetrahedral Oxyanions that Functions in Polar Media [PDF]

open access: yes, 2013
The pyrrole-based triazolium-phane 1(4+)center dot 4BF(4)(-) has been prepared via the tetraalkylation of a macrocycle originally prepared via click chemistry.
Cai, Jiajia   +4 more
core   +1 more source

Lithium adsorption properties of porous LiAl-layered double hydroxides synthesized using surfactants

open access: yesJournal of Saudi Chemical Society, 2022
Porous LiAl-layered double hydroxides (LiAl-LDHs) of [Li2Al4(OH)12](CO3)·4H2O were hydrothermally synthesized in one-pot by mixing LiCl, AlCl3, urea, and one surfactant each (sodium dodecyl sulfate (SDS), octadecyl amine (OA), and sodium lauryl sulfonate
Mingzhe Dong   +4 more
doaj  

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Fabrication of salt–hydrogel marbles and hollow-shell microcapsules by an aerosol gelation technique [PDF]

open access: yes, 2014
We designed a new method for preparation of liquid marbles by using hydrophilic particles. Salt–hydrogel marbles were prepared by atomising droplets of hydrogel solution in a cold air column followed by rolling of the collected hydrogel microbeads in a ...
Mehl, Georg H.   +4 more
core   +1 more source

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