Results 71 to 80 of about 781,833 (301)

Multiple representations in web-based learning of chemistry concepts [PDF]

, 2003
A new chemistry curriculum for secondary schools is currently under construction in the Netherlands, in which chemical knowledge will be embedded in contexts that show applications of chemistry in the society. Several research groups develop such modules
Dijkstra, Sanne, Terlouw, Cees, Vermaat, Han   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigations of Zr(IV) in LiF-CaF2: stability with oxide ions and electroreduction pathway on inert and reactive electrodes [PDF]

, 2013
In this work, a detailed electrochemical study of the molten LiF-CaF2-ZrF4 system is provided in the 810-920°C temperature range, allowing the determination of the reduction potential, the diffusion coefficient and the reduction mechanism of dissolved Zr(
Cassayre, Laurent, Chamelot, Pierre, Gibilaro, Mathieu, Massot, Laurent, Taxil, Pierre   +4 more
core   +4 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

N-Methylimidazole Promotes The Reaction Of Homophthalic Anhydride With Imines [PDF]

, 2014
The addition of N-methylimidazole (NMI) to the reaction of homophthalic anhydride with imines such as pyridine-3-carboxaldehyde-N-trifluoroethylimine (9) reduces the amount of elimination byproduct and improves the yield of the formal cycloadduct ...
Aaron Levin, Bally T., Bogdanov M. G., David M. Floyd, Deng W., Flannery E. L., González-López M., Guibe-Jampel E., Guiguemde W. A., Haimova M. A., Höfle G., Jain R., Jian Liu, Kandinska M. I., Lenarcik B., Lindner C., Lutnæs O. B., Pattawong O., Paul R. Rablen, Scriven E. F. V., Spencer Knapp, Taydakov I. V., Thomas J. Emge, Vara Y., Yu N., Zheng Wang   +25 more
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Salt release from potato crisps [PDF]

, 2012
The rate of salt release in-mouth from salted potato crisps was evaluated. It was hypothesised that a slow steady release of sodium would occur on chewing and hydration; to test this a crisp was chewed and held in the oral cavity without swallowing for
Barylkopikielna, Bertino, Busch, Davidson, de Loubens, Delwiche, Ferry, Ferry, Koliandris, Meiselman, Mitchell, Morris, Morris, Neyraud, Sacks, Shamil, Stampanoni, Ventanas   +17 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

Molecules, 2018
The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form ...
Deepak Gupta, Deepak Bhatia, Vivek Dave, Vijaykumar Sutariya, Sheeba Varghese Gupta   +4 more
doaj   +1 more source

Airborne sampling of aerosol particles: Comparison between surface sampling at Christmas Island and P-3 sampling during PEM-Tropics B [PDF]

, 2002
Bulk aerosol sampling of soluble ionic compounds from the NASA Wallops Island P-3 aircraft and a tower on Christmas Island during PEM-Tropics B provides an opportunity to assess the magnitude of particle losses in the University of New Hampshire airborne
Andreae, Atlas, Atlas, Atlas, Bandy, Bates, Bates, Baumgardner, Blake, Blake, Blake, Blanchard, Carolyn Jordan, Chin, Clarke, Davis, Davis, Dibb, Dibb, Dibb, Dibb, Dibb, Donald R. Blake, Elliot Atlas, Eric Scheuer, Garry Seid, Giannakopoulos, Giannakopoulos, Guelle, Huebert, Huebert, Huebert, Jack E. Dibb, Jacob, Neele, Nicola J. Blake, Nowack, Oncley, Porter, Quinn, Quinn, Raper, Robert W. Talbot, Savoie, Xiao   +44 more
core   +3 more sources