Results 81 to 90 of about 744,891 (357)
Exploring the scope of DBU-promoted amidations of 7-carboxymethyl-pterin [PDF]
, 2020 Pteridines are an important heterocycle often used in the development of pharmaceutically relevant compounds, and in the field of supramolecular chemistry.
Bockman, Anna
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Attractive forces in microporous carbon electrodes for capacitive deionization [PDF]
, 2013 The recently developed modified Donnan (mD) model provides a simple and useful description of the electrical double layer in microporous carbon electrodes, suitable for incorporation in porous electrode theory.
Bazant, M. Z. +3 more
core +4 more sources
Kinetics and mechanisms of the acid-base reaction between NH$_3$ and HCOOH in interstellar ice analogs [PDF]
, 2016 Interstellar complex organic molecules (COMs) are commonly observed during star formation, and are proposed to form through radical chemistry in icy grain mantles. Reactions between ions and neutral molecules in ices may provide an alternative cold channel to complexity, as ion-neutral reactions are thought to have low or even no energy barriers.
arxiv +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Influence of lowland forests on subsurface salt accumulation in shallow groundwater areas [PDF]
, 2013 In flat sedimentary plains in areas with a sub-humid climate, tree planting on grasslands and arable lands creates strong hydrological shifts. As a result of deep rooting and high water uptake of trees, groundwater levels drop and subsurface salt ...
Balog, Kitti +6 more
core +2 more sources
FEBS Open Bio, EarlyView.We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui +5 more
wiley +1 more source
Materials & Design, 2020 The H1.6Mn1.6O4 (HMO) derived from Li1.6Mn1.6O4 (LMO) has been aroused enormously attention due to high adsorption capacity. Through surface trace doping of F and S (LMO-R, R = F, S), the cycling stabilities and adsorption abilities of Li1.6Mn1.6O4 are ...
Fangren Qian +5 more
doaj
Inclusion of chemical effect in a fully coupled THM finite element code [PDF]
, 2018 Bentonite-rich clays can be used as a buffer / backfill material in deep geological repositories for nuclear waste. The prediction of the long-term performance of a buffer / backfill in such a complex environment, where the temperature, humidity and ...
Abed, A. A. +3 more
core
Evidence of ammonium salts in comet 67P as explanation for the nitrogen depletion in cometary comae [PDF]
arXiv, 2019 Cometary comae are generally depleted in nitrogen. The main carriers for volatile nitrogen in comets are NH3 and HCN. It is known that ammonia readily combines with many acids like e.g. HCN, HNCO, HCOOH, etc. encountered in the interstellar medium as well as in cometary ice to form ammonium salts (NH4+X-) at low temperatures.
arxiv