Results 11 to 20 of about 1,408,717 (297)

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

eLife, 2021
Cancer cells undergo lineage switching during natural progression and in response to therapy. NKX2-1 loss in human and murine lung adenocarcinoma leads to invasive mucinous adenocarcinoma (IMA), a lung cancer subtype that exhibits gastric differentiation
Rediet Zewdu, Elnaz Mirzaei Mehrabad, Kelley Ingram, Pengshu Fang, Katherine L Gillis, Soledad A Camolotto, Grace Orstad, Alex Jones, Michelle C Mendoza, Benjamin T Spike, Eric L Snyder   +10 more
doaj   +1 more source

Cumulative Incidence of Revision for a Balanced Knee System at a Mean 8-Year Follow-Up: A Retrospective Review of 500 Consecutive Total Knee Arthroplasties

Advances in Orthopedics, 2019
Purpose. The primary purpose of this study was to evaluate mid-term survival of a Balanced Knee System in the first 500 total knee arthroplasty (TKA) cases using a fully cemented, posterior stabilized TKA at a high-volume private practice.
Michael H. Bourne, Tony L. Miller, E. Marc Mariani   +2 more
doaj   +1 more source

The Biogeography of Great Salt Lake Halophilic Archaea: Testing the Hypothesis of Avian Mechanical Carriers

Diversity, 2018
Halophilic archaea inhabit hypersaline ecosystems globally, and genetically similar strains have been found in locales that are geographically isolated from one another.
Bex L. Kemp, Erin M. Tabish, Adam J. Wolford, Daniel L. Jones, Jaimi K. Butler, Bonnie K. Baxter   +5 more
doaj   +1 more source

Vitamin D supplementation protects against reductions in plasma 25‐hydroxyvitamin D induced by open‐heart surgery: Assess‐d trial

Physiological Reports, 2021
Low vitamin D (serum or plasma 25‐hydroxyvitamin D (25(OH)D)) is a global pandemic and associates with a greater prevalence in all‐cause and cardiovascular mortality and morbidity.
Tyler Barker, Heidi T. May, John R. Doty, Donald L. Lappe, Kirk U. Knowlton, John Carlquist, Kristin Konery, Shannon Inglet, Ben Chisum, Oxana Galenko, Jeffrey L. Anderson, Joseph B. Muhlestein   +11 more
doaj   +1 more source

A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas

Neoplasia: An International Journal for Oncology Research, 2014
The proto-oncogene proviral integration site for moloney murine leukemia virus (PIM) kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases that are involved in a number of signaling pathways important to cancer cells.
Jason M. Foulks, Kent J. Carpenter, Bai Luo, Yong Xu, Anna Senina, Rebecca Nix, Ashley Chan, Adrianne Clifford, Marcus Wilkes, David Vollmer, Benjamin Brenning, Shannon Merx, Shuping Lai, Michael V. McCullar, Koc-Kan Ho, Daniel J. Albertson, Lee T. Call, Jared J. Bearss, Sheryl Tripp, Ting Liu, Bret J. Stephens, Alexis Mollard, Steven L. Warner, David J. Bearss, Steven B. Kanner   +24 more
doaj   +1 more source

Implementation of Pit Crew Approach and Cardiopulmonary Resuscitation Metrics for Out‐of‐Hospital Cardiac Arrest Improves Patient Survival and Neurological Outcome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
IntroductionSurvival from out‐of‐hospital cardiac arrest (OHCA) varies by community and emergency medical services (EMS) system. We hypothesized that the adoption of multiple best practices to focus EMS crews on high‐quality, minimally interrupted ...
Christy L. Hopkins, Chris Burk, Shane Moser, Jack Meersman, Clair Baldwin, Scott T. Youngquist   +5 more
doaj   +1 more source

The Waters of the Great Salt Lake [PDF]

Science, 1889
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openaire   +3 more sources

An Evaluation of Type 1 Interferon Related Genes in Male and Female-Matched, SARS-CoV-2 Infected Individuals Early in the COVID-19 Pandemic

Viruses
SARS-CoV-2 infection has claimed just over 1.1 million lives in the US since 2020. Globally, the SARS-CoV-2 respiratory infection spread to 771 million people and caused mortality in 6.9 million individuals to date.
Tom P. Huecksteadt, Elizabeth J. Myers, Samuel E. Aamodt, Shubhanshi Trivedi, Kristi J. Warren   +4 more
doaj   +1 more source

Frequency of Thrombotic Risk Factors in Patients with Chronic Thromboembolic Pulmonary Hypertension and Acute Pulmonary Embolism: A Case-Control Study

Clinical and Applied Thrombosis/Hemostasis, 2022
Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious complication of acute pulmonary embolism (PE) which remains underdiagnosed. A better understanding of risk factors for CTEPH would improve our ability to predict which PE survivors are at
Mark W. Dodson MD, PhD, Meghan M. Cirulis MM, MD, Haojia Li MS, Zhang Yue PhD, Lynette M. Brown MD, PhD, C. Gregory Elliott MD   +5 more
doaj   +1 more source

Glutamine Metabolite Ratios are Related to Thwarted Belongingness and Perceived Burdensomeness: Preliminary Evidence from a Veteran Sample with and Without History of Suicidal Ideation

Chronic Stress
Background Suicidal thoughts and behaviors are an acute public health issue, particularly among US Veterans. The interpersonal-psychological theory of suicide posits that unmet interpersonal needs, specifically thwarted belongingness (TB) and perceived ...
James R. Yancey PhD, Punitha Subramaniam PhD, Jiyoung Ma PhD, Chelsea N. Carson PhD, Keenan E. Roberts MS, Erin C. McGlade PhD, Perry F. Renshaw MD, PhD, Deborah A. Yurgelun-Todd PhD   +7 more
doaj   +1 more source