SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo +14 more
wiley +1 more source
Molecular Mechanisms of Growth and Salt Tolerance in Diverse Rice Cultivars Balanced by Rhodobium marinum RH-AZ. [PDF]
Xu C +7 more
europepmc +1 more source
Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice
This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang +9 more
wiley +1 more source
Genome-wide characterization of cytochrome P450 genes in Solanum tuberosum and StCYP481 role in salt tolerance. [PDF]
Hou H +10 more
europepmc +1 more source
Synergistic control of surface uniformity and solid–electrolyte interphase robustness regulates potassium deposition, suppressing dendritic growth and enabling uniform, dense potassium plating. This combined strategy promotes stable interfacial chemistry and homogeneous electric‐field distribution, leading to enhanced reversibility and long‐term ...
Pan He +13 more
wiley +1 more source
Divergent Roles of <i>SOG</i> Family Genes in Salt Tolerance: A Comparative Genomics Study Between Barley and Rice. [PDF]
Weng Y +6 more
europepmc +1 more source
CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu +13 more
wiley +1 more source
Identification and Validation of <i>qSTS5</i>, a QTL Associated with Salt Tolerance at Seedling Stage in Dongxiang Wild Rice. [PDF]
Yan YJ +13 more
europepmc +1 more source
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena +2 more
wiley +1 more source
Genome-Wide Association Study Identifies Candidate Genes for Salt Tolerance in Traditional Rice Landraces. [PDF]
Liang H +7 more
europepmc +1 more source

