Results 241 to 250 of about 22,099 (300)

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Intracellular Reactive Oxygen Species Generation Induced by High‐Frequency Ultrasound in Thickness Vibration Mode

Advanced Science, EarlyView.
Cell‐sized high‐frequency ultrasound using a lithium niobate transducer, previously ignored in reactive oxygen species (ROS) production, generated intracellular ROS at frequencies higher than conventionally used. The intracellular generation of ROS by cell‐sized high‐frequency ultrasound revealed in this study is expected to be applied to innovative ...
Kotaro Fujishiro, Satoshi Okada, Filippo Rossi, Takahiro Kuchimaru, Yuta Kurashina   +4 more
wiley   +1 more source

Spicy or Not? Exploring Kimchi's Spiciness Perception Across Spicy Food Tolerant and Sensitive Groups. [PDF]

J Food Sci
Chon SY, Kim MK.
europepmc   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Bidirectional and mediation Mendelian randomization of dietary intake and risks of gastric ulcer and gastric cancer. [PDF]

Medicine (Baltimore)
Yang L, Li L, Chen L, Liu Z, Cai J, Wang W, Yang M, He Y, Meng Z, Li F, Wang Y, Luo X.   +11 more
europepmc   +1 more source

Effects of Different Conservation Methods on Minerals Level Sand Nutritional Value of Dried, Salted, Smoked and Sundried Fish

Journal of Dairy & Veterinary sciences
Mpho Sylvia Tsheole, Keitiretse Molefe
openaire   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Fish consumption and gastric cancer within the Stomach cancer Pooling (StoP) Project. [PDF]

Sci Rep
Franchi C, Ardoino I, Mandelli S, Patel L, Pelucchi C, Bonzi R, Camargo MC, Rabkin CS, Liao LM, Sinha R, Johnson KC, Hu J, Zhang ZF, Palli D, Ferraroni M, Negri E, Turati F, Yu GP, Lunet N, Morais S, López-Carrillo L, Tsugane S, Hidaka A, Malekzadeh R, Zaridze D, Maximovitch D, Vioque J, Gonzalez-Palacios S, Ward MH, Aragonés N, Castaño-Vinyals G, Curado MP, Dias-Neto E, Hamada GS, Hernández-Ramirez RU, Pakseresht M, Pourfarzi F, Mu L, Lagiou A, Lagiou P, López-Cervantes M, Dolci A, Boccia S, Pastorino R, Boffetta P, D'Avanzo B, La Vecchia C.   +46 more
europepmc   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Mendelian Randomisation Analysis of Dietary Exposures and Potential Risks of Anxiety and Depression. [PDF]

Actas Esp Psiquiatr
Yu X, Hang R, Gan Q, Peng J.
europepmc   +1 more source