Results 261 to 270 of about 339,512 (292)

[Some contributions of the COVID-19 pandemic to learning on public health,clinical and management]. [PDF]

An Sist Sanit Navar
March JC.
europepmc   +1 more source

Resolving Artifacts in Voltage‐Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings

Advanced Science, EarlyView.
Patch‐clamp experiments are fundamental to the measurement and understanding of ion currents that underlie physiological functions from neural activity to muscle contraction. Via a mathematical model of the experimental apparatus, this article highlights how artifact effects can be as large as some reported mutation and drug effects, and enables ...
Chon Lok Lei, Alexander P. Clark, Michael Clerx, Siyu Wei, Meye Bloothooft, Teun P. de Boer, David J. Christini, Trine Krogh‐Madsen, Gary R. Mirams   +8 more
wiley   +1 more source

Correction: Deciphering long-term immune effects of HIV-1/SARS-CoV-2 co-infection: a longitudinal study. [PDF]

Med Microbiol Immunol
Vazquez-Alejo E, De La Sierra Espinar-Buitrago M, Magro-Lopez E, Tarancon-Diez L, Díez C, Bernardino JI, Rull A, De Los Santos I, Alonso R, Zamora A, Jiménez JL, Muñoz-Fernández MÁ.   +11 more
europepmc   +1 more source

Neutrophil Macrophage Crosstalk via Extracellular Vesicles Drives Reverse Migration in a Fully Human Model of Wound Healing

Advanced Science, EarlyView.
A novel microphysiological system that can mimic sterile or non‐sterile injury demonstrates that macrophage‐derived extracellular vesicles modulate neutrophil migratory responses to these different wound states. The model showed that resolution of inflammation through neutrophil reverse migration is driven by IL‐8 derived from extracellular vesicles ...
Kehinde Adebayo Babatunde, Oluwadamilola Fatimat Babatunde, Adeel Ahmed, Wilmara Salgado‐Pabon, David J Beebe, Sheena C. Kerr   +5 more
wiley   +1 more source

Resúmenes [PDF]

Revista Argentina de Salud Pública, 2010
Comisión Nacional Salud Investiga.
doaj  

[Technical cooperation strategies to revitalize immunization programs in priority countries in the AmericasEstratégias de cooperação técnica para revitalização do programa de imunização em países prioritários da Região das Américas]. [PDF]

Rev Panam Salud Publica
Pastor D, Villavicencio V, Durón R, Bravo P, Rey-Benito G.   +4 more
europepmc   +1 more source

Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression

Advanced Science, EarlyView.
GLed, a reversible lanthanide‐based GSH sensor that enables real‐time, single‐cell measurement of Gamma–Glutamyl Cysteine Ligase (GCL) activity ‐whose role in human T cells remains unclear‐ is developed. GLed directly links GCL activity to T cell effector functions and reveals its modulation by immunosuppressive drugs, identifying GCL as a critical ...
Francisco Fueyo‐González, Carmen Salto‐Giron, Mehek Ningoo, Laura Espinar‐Barranco, Rafael Salto, Jose Manuel Paredes, Rosario Herranz, Angel Orte, Miguel Fribourg, Juan A. González‐Vera   +9 more
wiley   +1 more source

Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease. [PDF]

Alzheimers Dement
Bernhardt AM, Rodríguez-Baz Í, Aldecoa I, Arranz J, Arriola-Infante JE, Maure-Blesa L, Carmona-Iragui M, Longen S, Trossbach SV, Giese A, Matthias T, Benejam B, Videla L, Del Hoyo Soriano L, Barroeta I, Sanjuan A, Fernández S, Vaqué-Alcázar L, Rozalem Aranha M, Morcillo-Nieto AO, Nübling G, Wagemann O, Stockbauer A, Tondo M, Bejanin A, Lleó A, Alcolea D, Molina-Porcel L, Fortea J, Levin J.   +29 more
europepmc   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source