Results 271 to 280 of about 339,512 (292)

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source

[Mortality coding with ICD-11 in Chile: main results and prospects for implementationCodificação da mortalidade com a CID-11 no Chile: principais resultados e perspectivas de implementação]. [PDF]

Rev Panam Salud Publica
Vera Montecinos P, Pacheco J, Guinez-Molinos S, Piedra D, Velozo L, Fuentes A, Carmona M, Landabur A, Suárez P, Leighton P.   +9 more
europepmc   +1 more source

A Two‐Component Pseudo‐Icosahedral Protein Nanocompartment with Variable Shell Composition and Irregular Tiling

Advanced Science, EarlyView.
The structure and assembly principles of a two‐component encapsulin nanocompartment shell are reported. The two‐component protein compartment self‐assembles from two distinct HK97‐fold shell proteins into a pseudo‐icosahedral protein shell with variable composition and irregular tiling.
Cassandra A. Dutcher, Michael P. Andreas, Tobias W. Giessen   +2 more
wiley   +1 more source

Perception and experience of obstetric violence in postpartum women at a public hospital in Peru: a mixed study. [PDF]

Rev Peru Med Exp Salud Publica
Marcos-Garces PM, Moran-Ruiz SM, Santos-Rosales YR, Correa-Lopez MY.   +3 more
europepmc   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

Correction to "TRIM25 mutation (p.C168*), coding for an E3 ubiquitin ligase, is a cause of early-onset autosomal dominant dementia with amyloid load and Parkinsonism." [PDF]

Alzheimers Dement
europepmc   +1 more source

Dietary Patterns and Sustainable Lifestyles: A Multicenter Study from Latin America and Spain. [PDF]

Foods
Parra-Soto S, Carpio-Arias TV, Rios-Castillo I, Pérez-Armijo P, Landaeta-Díaz L, Murillo AG, Araneda-Flores J, Cavagnari BM, Gómez G, Morales G, Cordón-Arrivillaga K, Miranda-Durán M, Aguilar AM, Ortiz A, Meza-Miranda ER, Nava-González EJ, Bejarano-Roncancio JJ, Núñez-Martínez B, Lima JPM, de Assis Costa J, Torres J, Mauricio S, Camacho S, Morales GM, Jara M, Durán-Agüero S.   +25 more
europepmc   +1 more source

[ECoTES index of occupational safety and health (OSH) system performance: results of a pilot study in six Ibero-American countriesÍndice ECoTES de desempenho do sistema de segurança e saúde no trabalho: resultados de um estudo-piloto em seis países ibero-americanos]. [PDF]

Rev Panam Salud Publica
Benavides FG, Cornelio C, Carmenate L, Barraza D, Gimeno Ruiz de Porras D, Vives A, Rojas M, Palomo L, López-Ruiz M, Amable M, Merino-Salazar P, Silva-Peñaherrera M.   +11 more
europepmc   +1 more source