Results 161 to 170 of about 289,109 (230)

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Translation, cross-cultural adaptation, and validation of the HCT frailty scale for hematopoietic stem cell transplant candidates: an observational study. [PDF]

Hematol Transfus Cell Ther
Lorca L, Puga Larrain B, Leao Ribeiro I, Gonzalez Valdivia I, Fernández Hermoso A, Bass Maturana F, Canelo Lazcano F.   +6 more
europepmc   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

[Chronic pain and persistent pain: Conceptual and clinical differences in pain terminology]. [PDF]

Aten Primaria
Vázquez Canales LM, Perelló-Bratescu A, Domínguez-García M, Morral Fernández A.   +3 more
europepmc   +1 more source

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu, Rajasekar Nagarajan, Dishary Sharmin, Prithu Mondal, Maltesh Kambali, Muxiao Wang, Jinyan Zhou, Makoto Inoue, James M. Cook, Uwe Rudolph   +9 more
wiley   +1 more source

Loneliness in caregivers of people with chronic illnesses: conceptual analysis according to Walker and Avant. [PDF]

Rev Bras Enferm
Medina CPC, Lopes MVO, Silva VM, Barreiro RG, Coutinho JFV, Ramírez-Perdomo CA.   +5 more
europepmc   +1 more source

Reconsidering the role of introduced species in the climate‐affected and highly invaded eastern Mediterranean

Conservation Biology, EarlyView.
Abstract Bioinvasions are considered mostly as a biodiversity and conservation hazard, but in specific situations, introduced species can bring ecological or socioeconomic benefits. We assessed the social–ecological role of marine introduced species in the eastern Mediterranean Sea—a global hotspot of bioinvasions and extirpations—and their potential ...
Stelios Katsanevakis, Jonathan Belmaker, Gil Rilov, Erez Yeruham, Andreas Konstantinidis, Maria Papazekou, Sylvaine Giakoumi, Antonios D. Mazaris   +7 more
wiley   +1 more source

[Systemic capillary leak syndrome: A case of severe presentation and treatment response]. [PDF]

An Sist Sanit Navar
Lasierra Lavilla I, Fonseca López C, Escuer Núñez IE, Lerín Sánchez FJ.   +3 more
europepmc   +1 more source

Performance outcomes of the PEDI‐CAT for assessing functional ability in the population with leukodystrophy

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To describe the use of the Pediatric Evaluation of Disability Index‐Computer Adapted Test (PEDI‐CAT), a parent‐reported outcome, and determine functional performance in a cohort with leukodystrophy. Method This was a cross‐sectional observational study.
Stacy V. Cusack, Allan M. Glanzman, Francesco Gavazzi, Sarah Woidill, Abbas F. Jawad, Timothy Estilow, Amy T. Waldman, Adeline Vanderver, Laura Adang, Children's Hospital of Philadelphia Leukodystrophy Workgroup, Todd Levy, Michelle Fitzgerald, Ann T. Harrington, Emma McKenzie, Elizabeth Balance, Tracy Kornafel, Kaleb Kelley, Peter Hong, Sarah Pham, Aaliyah White, Miriam Lerner   +20 more
wiley   +1 more source