Results 211 to 220 of about 586,963 (259)
ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis
The FEBS Journal, EarlyView.The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao +4 morewiley +1 more sourceMissed opportunities to prevent HIV acquisition with pre‐exposure prophylaxis: A mixed methods study of people with recently acquired HIV in the United Kingdom
HIV Medicine, EarlyView.Abstract Objectives
To explore missed opportunities for PrEP use among people with recently acquired HIV in the United Kingdom. Methods
Data were derived from CASCADE, an international, longitudinal, mixed‐methods study of adults (≥16 years) with recently acquired HIV (≤12 months).Argyro Karakosta, Emily Jay Nicholls, Flavien Coukan, Diarmuid Nugent, Iain Reeves, Laura Waters, Sarah Fidler, Elisa Ruiz Burga, Julie Fox, Alison Uriel, Jane Nicholls, Claire Mackintosh, Shema Tariq, Fiona Burns, for CASCADE Collaboration, John Gill, Kholoud Porter, Fiona Burns, Christina Carlander, Rafael Eduardo Campo, Harmony Garges, Sophie Grabar, Inma Jarrín, Laurence Meyer, Moustafa Kamel, Shema Tariq, Giota Touloumi, Marc van der Valk, Vani Vannappagari, Alain Volny Anne, Linda Wittkop, Lital Young, Agnes Aisam, Diana Barger, Eli Fitzgerald, Argyro Karakosta, Emily Jay Nicholls, Nicoletta Policek, Bruno Spire, Inés Suárez‐García, Sophie Abgrall, Valerie Andriantsoanirina, Veronique Avettand‐Fenoel, Christine Bourgeois, Marie‐Laure Chaix, Antoine Cheret, Hugues Fischer, Cecile Goujard, Caroline Lascoux‐Combe, Annie Le Palec, Ventzlislava Petrov‐Sanchez, Asier Saez‐Cirion, Remonie Seng, Karl Stefic, Josephine Tine, E Piet, A Gagneux‐Brunon, C Jacomet, L Piroth, F Benezit, M Goussef, P Tattevin, F Bani Sadr, I Lamaury, M Nacher, H Bazus, O Robineau, R Calin, C Katlama, JL Meynard, B Denis, J Ghosn, V Joly, MA Khuong, F Caby, E Rouveix Nordon, P de Truchis, S Abgrall, A Chéret, C Duvivier, A Becker, P Miailhes, S Abel, G Unal, A Makinson, G Martin‐Blondel, A Morisot, S Bregigeon, C Allavena, V Rabier, H Fischer, L Vallet, L Marchand, T Saïdi, D Costagliola, S Grabar, Pierre Tattevin, Pierre de Truchis, M Hughes Fischer, Santiago Moreno, David Dalmau, M Luisa Navarro, M Isabel González, Federico Garcia, Eva Poveda, Félix Gutiérrez, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M Ángeles Muñoz‐Fernández, G. Adamis, M. Chini, G. Chrysos, M. Marangos, O. Katsarou, D. Kofteridis, S. Metallidis, P. Panagopoulos, N. Pantazis, A. Papadopoulos, V. Paparizos, V. Papastamopoulos, M. Psychogiou, H. Sambatakou, NV. Sipsas, G. Touloumi, C Thomadakis, Julie Fox, Louise Terry, Alison Uriel, Sarah Fidler, Wilbert Ayap, Laura Waters, Fowsiya Nur, Sabine Kinloch, Thomas Fernandez, Diarmuid Nugent, Javier Pinedo, Iain Reeves, Lidia Ignatov, Tracy Fong, Laura Cunningham, Jaydee Pangan, Claire Mackintosh, Louise Sharp +145 morewiley +1 more sourceGenetic Determinants of Peanut‐Specific IgG4 Levels in the Context of Sustained Oral Peanut Exposure in the LEAP Study
Immunology, EarlyView.A cumulative genetic score based on IgG4‐associated variants explains a substantial proportion of variance in psIgG4 levels during sustained peanut consumption, highlighting strong gene‐by‐environment interactions. Our findings suggest that early, sustained peanut consumption, in combination with genetic factors, promotes a protective immune response ...Kanika Kanchan, Karen Cerosaletti, James A. Perry, George DuToit, Monali Manohar, Hua Ling, Justin E. Paschall, Srinath Sanda, R. Sharon Chinthrajah, Gerald T. Nepom, Kari C. Nadeau, Stacie M. Jones, Gideon Lack, Ingo Ruczinski, Rasika A. Mathias +14 morewiley +1 more sourceBalancing and Exploring the Personal, Professional, and Political: Finding Space and Place in the Academy Through Reflexive and Intersecting Masculinities
Journal of Family Theory &Review, EarlyView.ABSTRACT
Using critical intersectional feminist theorizing, I engage in praxis around reflexive masculinities. I discuss my positionality through my personal lived experiences, professional career in academia, and my political engagement. I start by discussing my positionality related to my race, gender, sexual orientation, and family background, and ...Allen B. Mallorywiley +1 more sourcePerceptions of Medications and Supplements by U.S. Dog‐Interested Members of the Public and Final‐Year Veterinary Students
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT
Veterinary graduates must be prepared to educate clients about medications and supplements. We surveyed 1955 Dog Aging Project newsletter recipients and 40 final‐year veterinary students at Texas A&M College of Veterinary Medicine and Biomedical Sciences on their perceptions about medications and supplements. Respondents indicated whether each Sidonie T. Gallinger, Johanna C. Heseltine, Kate Illing, Virginia R. Fajt, Dog Aging Project Consortium, Joshua M. Akey, Brooke Benton, Elhanan Borenstein, Marta G. Castelhano, Amanda E. Coleman, Kate E. Creevy, Kyle Crowder, Matthew D. Dunbar, Virginia R. Fajt, Annette L. Fitzpatrick, Unity Jeffery, Erica C. Jonlin, Matt Kaeberlein, Elinor K. Karlsson, Kathleen F. Kerr, Jonathan M. Levine, Jing Ma, Robyn L. McClelland, Daniel E. L. Promislow, Audrey Ruple, Stephen M. Schwartz, Sandi Shrager, Noah Snyder‐Mackler, M. Katherine Tolbert, Silvan R. Urfer, Benjamin S. Wilfond, Kate E. Creevy +31 morewiley +1 more source