Results 211 to 220 of about 16,396,047 (272)

[Lifestyle pattern and therapeutic adherence in patients on hemodialysis]. [PDF]

Rev Med Inst Mex Seguro Soc
Trejo-Mena HA, Torres-Pedroza AJ, Solís-González AJ, Llanos-Sosa ÁJ, Rojas-Morales A, Balcázar-Rueda E, Mejía-Castellanos GH.   +6 more
europepmc   +1 more source

Primera edición del Congreso mujeres, y hombres: salud, ciencia y tecnología

Quark, 2003
openaire   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Brain Pathology, EarlyView.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni, Miguel Pellegrini, Aurora Savino, Martina Lazioli, Sarah Geurs, Lorenzo Graziani, Denise Ferrarini, Solaleh Khoramian Tusi, Esaria Oliver, Jarne Geurts, Sara Vinciguerra, Michele Tebaldi, Takshashila Tripathi, Isabella Pesce, Valeria Poli, Alessandro Romanel, Rosario Moratalla, Thierry Voet, Jasmin Morandell, Remo Sanges, Vanessa C. Wheeler, Erik Dassi, Marta Biagioli   +22 more
wiley   +1 more source

Years of life lost due to external causes in Honduras, 2013 - 2023. [PDF]

Rev Peru Med Exp Salud Publica
Rosales-Meléndez AA.
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

[Nurses' perceptions of the integration of patient-reported experience measures and patient-reported outcome measures for care improvement: A multicenter qualitative study]. [PDF]

An Sist Sanit Navar
Ruiz-Zaldibar C, Montes-Muñoz P, Ruano-Sanz M, Cidoncha-López D, Crespo-Hernández S, Segarra-Cañamares ML.   +5 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

[Becoming objects in the face of artificial intelligence]. [PDF]

Salud Colect
Spinelli H.
europepmc   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Key aspects of nursing practice that underpin certain discourses: an integrative review. [PDF]

Rev Bras Enferm
Macías MLC, Basurto SDÁ, Zambrano JAR, Quiroz JTG.   +3 more
europepmc   +1 more source