Results 181 to 190 of about 1,457,183 (310)

Machine Learning‐Based Development of Gadolinium Binding Peptides

open access: yesNMR in Biomedicine, Volume 39, Issue 10, October 2026.
In this study, Dayan et al. employed a machine‐learning‐driven peptide‐evolution platform, the Protein Optimization Engineering Tool (POET), to design and optimize short Gd‐binding motifs to enhance longitudinal relaxivity (r1). ABSTRACT Gadolinium‐based contrast agents (GBCAs) are indispensable tools in magnetic resonance imaging (MRI), yet their ...
Nir A. Dayan   +7 more
wiley   +1 more source

Function within disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation

open access: yesProtein Science, Volume 35, Issue 10, October 2026.
Abstract In numerous neurodegenerative diseases known collectively as tauopathies, the microtubule‐associated protein tau forms fibrillar aggregates that are hallmarks of disease pathology. Tauopathies represent a substantial fraction of diseases associated with protein misfolding.
Mia Cervantes   +5 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1759-1771, September 2026.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

Associations of Sleep and Shift Work With Osteoarthritis Risk

open access: yesArthritis Care &Research, Volume 78, Issue 9, Page 1209-1219, September 2026.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik   +5 more
wiley   +1 more source

La vigilancia de la salud en servicio del hogar familiar, ¿un ejemplo a seguir para otras ocupaciones?

open access: yesArchivos de Prevención de Riesgos Laborales
El trabajo del hogar familiar, esencial para la sostenibilidad de cualquier sociedad, pero sin el reconocimiento ni la valoración social que le corresponde, ha estado históricamente relegado a las mujeres y otros colectivos vulnerables, y, por lo tanto,
Fernando G. Benavides   +3 more
doaj  

Climate Exposures Increase the Risk of Anemia Among Reproductive‐Age Women in Low‐ and Middle‐Income Countries

open access: yesAmerican Journal of Human Biology, Volume 38, Issue 9, September 2026.
ABSTRACT Climate change is having significant demographic and health impacts on human populations around the world. There is growing empirical evidence about the impacts of climate variability and change on population health, but this work has focused disproportionately on children and aggregate indicators of weight and (or) height.
Alfredo J. Rojas Jr   +3 more
wiley   +1 more source

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