Results 21 to 30 of about 52,468 (237)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Nagrada za spašavanje kao šteta na teretu : [prikaz presude]
Uporedno pomorsko pravo, 1992 Članak 3. Konvencije iz 1976. o ograničenju odgovornosti brodara za pomorske tražbine, koji izuzima tražbine s naslova spašavanja od ograničenja odgovornosti, primjenjuje se samo na spašavatelje.
Dorotea Ćorić
doaj
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Pravni osvrt na spašavanje imovine na moru
Poredbeno Pomorsko Pravo, 2015 Plovidba morem, sa svim mogućim rizicima i izazovima koji se iza nje kriju, odavno je uvjetovala nastanak jednog specifičnog pravnog instituta – spašavanja, kroz koji se, po tko zna koji put, odražava ljudska solidarnost i spremnost na pomoć.
Jelena Nikčević Grdinić
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Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma [PDF]
, 2003 BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used
A du Bois +59 more
core +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Poredbeno Pomorsko Pravo, 2014 U radu se analizira aktivnost Međunarodnog pomorskog odbora u svezi prijedloga izmjena i dopuna Međunarodne konvencije o spašavanju iz 1989. godine. Autori raščlanjuju prijedloge koji su upućeni Međunarodnom pomorskom odboru na razmatranje, ocjenjuju ...
Igor Vio, Mišo Mudrić
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source