Results 81 to 90 of about 77,794 (334)

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Salvation Army Chief Is Speaker [PDF]

, 1953
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about the Salvation Army holding its annual meeting in ...
WBAP-TV (Television station : Fort Worth, Tex.)
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Navigating transitions into, through, and beyond peer worker roles: insider insights from the Supporting Harm Reduction through Peer Support (SHARPS) study

Harm Reduction Journal
Background Peer workers are individuals who draw on their personal experiences in a professional capacity to support clients. Existing research on the role of peer workers in mental health, homelessness, and substance use services has primarily focused ...
Josh Dumbrell, Hannah Carver, Rebecca Foster, Bernie Pauly, Wez Steele, Michael Roy, Tessa Parkes   +6 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Salvation as praxis: A practical theology of salvation for a multi-faith world [PDF]

, 2019
Will people of other faiths be 'saved' and to what extent should the response to this question shape Christian engagements with people of other faiths? Historically, the predominant answer to these questions has been that the person of another faith will
Morris, Wayne
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Digital Bordering of Polish Workers Registered with a D-Nummer in Norway: From Precarity to Welfare Exclusion and Work ExploitationFra prekære arbeidsforhold til velferdsekskludering og arbeidsutnyttelse: Polske arbeideres erfaringer med digitale grenser i Norge

Norsk Antropologisk Tidsskrift
In order to register as a resident in Norway and obtain a permanent personal identification number (fødselsnummer), EU citizens have to show proof that they have secured at least six months of future employment in Norway.
Aleksandra Czech-Havnerås, Mateus Schweyher   +1 more
doaj   +1 more source

Measuring Nutrition Security Using the Consumer Food Data System Datasets

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Nutrition security is an emerging concept lacking a consensus definition, conceptualization, or standardized measure. This perspectives manuscript synthesizes findings from two previously published analyses to assess the feasibility of using available measures of key dimensions of nutrition security from two Consumer Food Data System (CFDS ...
Vibha Bhargava, Jung Sun Lee, Travis A. Smith   +2 more
wiley   +1 more source

Salvation Army Appeal Campaign, 1970 -- 02 [PDF]

, 1970
Captain Smith sought assistance from Swinburne's Graphic Art Students for visual commentary on the areas of poverty and greatest need in the community. Left to right: Bob Francis, lecturer in the Art Faculty; Geoff Dance, lecturer in the Art Faculty; and
Swinburne College of Technology
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The implementation of safer drug consumption facilities in Scotland: a mixed methods needs assessment and feasibility study for the city of Edinburgh

Harm Reduction Journal
Background Scotland currently has amongst the highest rates of drug-related deaths in Europe, leading to increased advocacy for safer drug consumption facilities (SDCFs) to be piloted in the country.
James Nicholls, Wendy Masterton, Danilo Falzon, Andrew McAuley, Hannah Carver, Kathryn Skivington, Josh Dumbrell, Andy Perkins, Samantha Steele, Kirsten Trayner, Tessa Parkes   +10 more
doaj   +1 more source