Results 231 to 240 of about 232,052 (319)

Mavacamten for Left Ventricular Outflow Tract Obstruction After Successful Transcatheter Aortic Valve Implantation. [PDF]

open access: yesJACC Case Rep
Jo HH   +9 more
europepmc   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

open access: yesAdvanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan   +16 more
wiley   +1 more source

Area‐Selective Atomic Layer Deposition on Homogeneous Substrate for Next‐Generation Electronic Devices

open access: yesAdvanced Science, EarlyView.
This study demonstrates a self‐aligned passivation approach for grain boundaries on ZrO2 surfaces using area‐selective atomic layer deposition (AS‐ALD). Selective deposition of Al2O3 onto ZrO2 grain boundaries effectively enhances dielectric performance while tackling leakage pathways.
Min‐Jeong Rhee   +5 more
wiley   +1 more source

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

open access: yesAdvanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma   +13 more
wiley   +1 more source

Nanoneedle‐Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T‐Cells

open access: yesAdvanced Science, EarlyView.
Low reproducibility and inefficient gene transfer hamper clinical manufacturing of chimeric antigen receptor regulatory T cells (CAR Tregs). Nanoneedle mediated electroporation generates primary human CAR Tregs under good manufacturing practice conditions with superior efficiency compared to viral transduction.
Ningjia Sun   +12 more
wiley   +1 more source

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