Results 271 to 280 of about 2,499,224 (321)

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

A foundation model-driven multi-view collaborative framework for semi-supervised 3D medical image segmentation. [PDF]

Front Med (Lausanne)
Li L, Wang B, Zhang H.
europepmc   +1 more source

An Archaeological Survey of the Proposed Famcor Oil, Inc. Well Pads and Pipeline in the Sam Houston National Forest, San Jacinto County, Texas

, 2015
William Moore, Michael R. Bradle
openalex   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Optical Spin Angular Momentum: Properties, Topologies, Detection and Applications. [PDF]

Nanomaterials (Basel)
Liu S, Xie X, Shi P, Shen Y.
europepmc   +1 more source

Elisæi Klage und Trauer, über Eliæ seligem Abscheiden Und sein Nachruhm / Entworffen Jn einer Christlichen Leichen-Predigt Bey der ... BeErdigung, Des Weyland ... Herrn Joannis Bithneri, Gewesenen Hochverdienten Superintendenten und Senioris, dehrer Evangelischen Reform: Gemeinen in der Löblichen Unität B. C. durch GroßPohlen und Preußen, Von Adam Sam: Hartman: S. Th. Doct. itzo Superintendenten der Gedachten Gemeinen und Eltisten Prediger in Lissa.

Hartman, Adam Samuel (1627–1691)
openalex   +1 more source

Real‐Time High‐Definition Hyperspectral Endoscopy via Spatial‐Temporal Low‐Frequency‐Stochastic Spectral Encoding

Advanced Science, EarlyView.
A real‐time, high‐definition hyperspectral endoscopy is enabled by developing a spatial‐temporal spectral encoding approach based on low‐frequency stochastic filters combined with an encoding‐guided attention network. It provides hyperspectral image of in vivo tissue with fine superficial features, enables visualization of rapid and subtle ...
Xiaowei Liu, Jiakang Shao, Julin Xiao, Chenying Yang, Jiahe Zhang, Xiaoyu Yang, Xiang Hao, Ying Gu, Xu Liu, Yizhou Tan, Ji Qi, Qing Yang   +11 more
wiley   +1 more source

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells. [PDF]

Nat Commun
Rothweiler EM, Michaud A, Stefaniak J, Singh U, Mikulsky BB, Vasta JD, Beck MT, Wilkinson J, Ward JA, Rogers CM, Balıkçı E, Tranberg-Jensen J, Hansen JS, Loppnau P, Whitty A, Brennan PE, Tonge PJ, Robers MB, Huber KVM.   +18 more
europepmc   +1 more source

A weakly supervised framework for automated biological assay assessment. [PDF]

Virus Res
Jiang H, Guo Q, Zhi X, Li H, Chen Y.
europepmc   +1 more source

Gut microbiome and plasma metabolic signatures of one-carbon metabolism differentiate oedematous and non-oedematous severe acute malnutrition

Robertson RC, Edens TJ, Baharmand I, Varankovich N, Dumbura C, Panchal M, Mutasa K, Ntozini R, Chasekwa B, Mwakamui S, Francis F, Besa E, Runodamoto T, Ngosa D, Majo FD, Zyambo K, Bourke CD, Rukobo S, Govha M, Amadi B, Nathoo K, Bwakura-Dangarembizi M, Swann JR, Kelly P, Manges AR, Prendergast AJ.   +25 more
europepmc   +1 more source