Results 51 to 60 of about 6,949,480 (286)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

The subjective well-being penalty of same-sex couples relative to different-sex couples in Europe

open access: yesGenus
Despite major advances in the legal recognition of same-sex couples across Europe, persistent social stigma and institutional inequalities may continue to shape their subjective well-being (SWB).
Manuela Stranges, Daniele Vignoli
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Same-sex couples in Spain. Historical, contextual and symbolic factors [PDF]

open access: yes, 2004
Proceedings of the Stockholm Conference Stockholm University 25-26 September 2003 Edited by Marie Digoix & Patrick FestyDepto. de Antropología Social y Psicología SocialFac.
Pichardo Galán, José Ignacio
core   +1 more source

A judicial revolution?<br> The court-led achievement of same-sex marriage in South Africa

open access: yesUtrecht Law Review, 2008
This article maps the legal developments that led to the adoption of the Civil Union Act, which extended full marriage rights to same-sex couples in South Africa.
Pierre de Vos
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Political engagement and turnout among same-sex couples in Western Europe

open access: yesResearch & Politics, 2020
This paper presents and addresses a simple, yet overlooked, research question: is there a sexuality gap in political engagement and participation between sexual minority individuals and the heterosexual majority in Western Europe? To answer this question,
Stuart J. Turnbull-Dugarte   +1 more
doaj   +1 more source

Legal Recognition of Same-Sex Couples and Family Formation [PDF]

open access: yesDemography, 2015
Abstract It has long been debated how legalizing same-sex marriage would affect (different-sex) family formation. In this article, I use data on OECD member countries for the period 1980–2009 to examine the effects of the legal recognition of same-sex couples (through marriage or an alternative institution) on different-sex marriage ...
openaire   +4 more sources

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