Results 141 to 150 of about 16,471,227 (282)

(2) Sample Syllabus: Econ 4010 [PDF]

, 2009
Brush, Brian
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Three open questions in polygenic score portability. [PDF]

Nat Commun
Wang JY, Lin N, Zietz M, Mares J, Smith OS, Rathouz PJ, Harpak A.   +6 more
europepmc   +1 more source

(2) Sample Syllabus: Econ 3004 [PDF]

, 2009
Nourzad, Farrokh
core   +1 more source

A probabilistic language based upon sampling functions

, 2005
Sungwoo Park, Frank Pfenning, Sebastian Thrun   +2 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Validation of on-slide immunocytochemistry controls prepared from long-term preserved prefixed cell suspensions. [PDF]

Cancer Cytopathol
Roque RR, Srebotnik Kirbiš I, Pinheiro CSC, Martins RSF, Tavares VS, André S, Félix A.   +6 more
europepmc   +1 more source

(2) Sample Syllabus: Econ 1001 [PDF]

, 2010
Lephardt, Noreen
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Study on gas-water two-phase seepage law and flow characteristics of the matrix-fracture system in shale gas reservoirs. [PDF]

PLoS One
He S, Fang F, Chang J, Li X, Luo R, Zhang J.   +5 more
europepmc   +1 more source