Results 181 to 190 of about 1,264,517 (335)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Research on Underwater Target Detection Method Based on APO-DBSCAN Clustering. [PDF]

Sensors (Basel)
Duan S, Bian G, Liu Q, Xiong P.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Souporcell3: robust demultiplexing for high-donor single-cell RNA-seq datasets. [PDF]

Bioinformatics
Weerakoon M, Vu H, Behboudi R, Heaton H.
europepmc   +1 more source

Geographical distribution of the six super-clusters (SCs) and the selected provinces and capitals for sampling in Iran [25].

Rosa Haghshenas (7321367), Zahra Soleimani (9280331), Yosef Farzi (10431905), Amirmohammad Khalaji (14501090), Amir Hossein Behnoush (14501081), Ali Taherkhani (21526236), Ashkan Pourabhari Langroudi (17087706), Shahedeh Seyfi (16362324), Nasim Hadian (21526239), Mohammadhassan Momayyezi (21526242), Samaneh Mozafari (21526245), Samaneh Abolli (17385292), Kazem Naddafi (5521997), Masud Yunesian (21344), Alireza Mesdaghinia (1812976), Farshad Farzadfar (439490)   +15 more
openalex   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Number of cells per cluster for each sample.

Gabriela Madrid (11871401), Gabriel Angelo Saraiva Raimundo (22226814), Fabian Andres Reyes (22226817), Edgard Augusto de Toledo Picoli (22226820), Marcio F. R. Resende Jr. (22226823), Kelly M. Balmant (8938592)   +5 more
openalex   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

DWGCN: distance-weighted graph convolutional network for robust spatial domain identification in spatial transcriptomics. [PDF]

Front Genet
Peng C, Li G, Wu J, Fan Q, Guo X.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source