Results 71 to 80 of about 2,783,159 (312)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Select a Sample Site and Provide Sample Context

, 2012
Documents relating to the Select a Sample Site and Provide Sample Context collection of Objectives sub-series. This is part of the OSIRIS-REx Asteroid Return Mission Science Implementation Plan. Contains 1 files.This material is based upon work supported
OSIRIS-REx Asteroid Sample Return Mission
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Sample Preparation for X-ray Micro-computed Tomography of Woody Plant Material and Associated Xylem Visualisation Techniques

Bio-Protocol, 2016
Variation in the tissue structure of short rotation coppice (SRC) willow is a principle factor driving differences in lignocellulosic sugar yield yet much of the physiology and development of this tissue is unknown.
Nicholas Brereton
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Jarvis supplementary material (code and sample datasets)

, 2021
The zip file contains supplementary material including code and sample datasets used to evaluate our system ...
Atul Sandur
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Evaluation of GSJ intrusive rocks JG1, JG2, JG3, JG1a, and JGb1 by an objective outlier rejection statistical procedure

Revista Mexicana de Ciencias Geológicas, 2018
An objective procedure involving fourteen statistical tests (a total of thirty-four variants) for detection and rejection of outliers in a univariate sample was applied to five geochemical Reference Material (RM) databases of intrusive rocks from the ...
Mirna Guevara, Surendra P. Verma, Fernando Velasco-Tapia   +2 more
doaj  

1.1 Return ≥60 g of pristine bulk sample from Bennu and archive 75% of the total returned mass for future analyses. ‘Pristine’ is defined to mean that no foreign material introduced into the sample hampers the scientific analysis of the sample

, 2012
Documents relating to the 1.1 Return ≥60 g of pristine bulk sample from Bennu and archive 75% of the total returned mass for future analyses. ‘Pristine’ is defined to mean that no foreign material introduced into the sample hampers the scientific ...
OSIRIS-REx Asteroid Sample Return Mission
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source