Results 51 to 60 of about 381,051 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Minimal Information About Sample Preparation for Phosphoproteomics [PDF]

, 2009
This guideline describes parameters and conditions involved in phosphopeptide sample preparation. It covers from the description and preparation of the cells and tissues to the fractionation and specific enrichment of phosphopeptides for MS analysis. The
David Ovelleiro, Joaquin Abian, Marina Gay, Montserrat Carrascal   +3 more
core   +2 more sources

A Review of Current Methods for Analysis of Mycotoxins in Herbal Medicines

Toxins, 2018
The presence of mycotoxins in herbal medicines is an established problem throughout the entire world. The sensitive and accurate analysis of mycotoxin in complicated matrices (e.g., herbs) typically involves challenging sample pretreatment procedures and
Lei Zhang, Xiao-Wen Dou, Cheng Zhang, Antonio F. Logrieco, Mei-Hua Yang   +4 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Cognitive-behavioral therapy for obsessive-compulsive disorder: access to treatment, prediction of long-term outcome with neuroimaging. [PDF]

, 2015
This article reviews issues related to a major challenge to the field for obsessive-compulsive disorder (OCD): improving access to cognitive-behavioral therapy (CBT).
Feusner, Jamie D, O'Neill, Joseph
core   +2 more sources

Development and optimization of a digestion method for heavy metal determination in scleractinian corals by Atomic Absorption Spectrometry (AAS).

Ciencias Marinas, 2003
In the last decade a great number of studies have been directed especially to the evaluation of the environmental impact of heavy metal concentration levels in coral barriers.
MD Galindo-Riaño, L Castellón, K González, M García-Vargas   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The effect of ultrasound pretreatment on some selected physicochemical properties of black cumin (Nigella Sativa) [PDF]

, 2018
Background In the present study, the effects of ultrasound pretreatment parameters including irradiation time and power on the quantity of the extracted phenolic compounds quantity as well as on some selected physicochemical properties ...
A Jiménez, AM Goula, AOAC, AOCS, AR Jambrak, AS Oktay, B Khadhraoui, BJ Arends, E Halawani, EA Decker, F Chemat, F Chemat, F Chemat, F Yamaguchi, H Bakhshabadi, H Haron, HRH Takruri, IUPAC, JA Carcel, JL Luque-Garcia, JY Lin, L Han, L Zhang, M Corrales, M Ghavami, M Jacotet-Navarro, M Kebriti, M Pinelo, M Toma, M Vintoru, M Virot, PN Giannelos, S Abdullah, S Machmudah, S Samaram, S Zhao, S Zomorrodi, SK Tiruppur Venkatachallam, SR Shirsath, SU Kadam, TJ Mason, W Lingyun, ZS Zhang   +42 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data [PDF]

, 2017
Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear.
Altemus, Margaret, Anderson, Page, Andersson, Erik, Cukor, Judith, Davis, Michael, DCS Anxiety Consortium, de Kleine, Rianne A., Difede, JoAnn, Dunlop, Boadie W., Farrell, Lara J., Fernández de la Cruz, Lorena, Finck, Claudia, Frumento, Paolo, Geffken, Gary R., Geller, Daniel, Gerardi, Maryrose, Golfels, Fabian, Goodman, Wayne K., Guastella, Adam J., Gutner, Cassidy, Hendriks, Gert-Jan, Heyman, Isobel, Hofmann, Stefan G., Jovanovic, Tanja, Kushner, Matt G., Lee, Francis S., Lenze, Eric J., Levinson, Cheri A., Lewin, Adam B., Mataix-Cols, David, McConnell, Harry, McNamara, Joseph P., Monzani, Benedetta, Murphy, Tanya K., Norrholm, Seth, Otto, Michael W., Plag, Jens, Pollack, Mark H., Pérez-Vigil, Ana, Ressler, Kerry J., Rodebaugh, Thomas L., Rosenfield, David, Rothbaum, Barbara O., Rück, Christian, Scheeringa, Michael S., Siewert-Siegmund, Anja, Smits, Jasper A.J., Storch, Eric A., Ströhle, Andreas, Tart, Candyce D., Thuras, Paul, Tolin, David F., van Minnen, Agnes, Waters, Allison M., Weems, Carl F., Wilhelm, Sabine, Wyka, Katarzyna   +56 more
core   +1 more source