Results 121 to 130 of about 690,202 (278)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Sample Size Calculation and Power Analysis of Time-Averaged Difference

, 2005
Little research has been done on sample size and power analysis under repeated measures design. With detailed derivation, we have shown sample size calculation and power analysis equations for timeaveraged difference to allow unequal sample sizes between
Wu, Tongtong, Honghu Liu, Liu, Honghu, Tongtong Wu   +3 more
core   +1 more source

artcat: Sample-size calculation for an ordered categorical outcome. [PDF]

Stata J, 2023
White IR, Marley-Zagar E, Morris TP, Parmar MKB, Royston P, Babiker AG.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Rational Arithmetic Mathematica Functions to Evaluate the Two-Sided One Sample K-S Cumulative Sampling Distribution

One of the most widely used goodness-of-fit tests is the two-sided one sample Kolmogorov-Smirnov (K-S) test which has been implemented by many computer statistical software packages.
J. Randall Brown, Milton E. Harvey
core  

Analysis of covariance and sample size calculation for comparing means in randomized controlled trials. [PDF]

J Cardiovasc Thorac Res, 2023
Alimohamadi Y, Sepandi M.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Three-stage cluster sampling and sample size calculation.

Three-stage cluster sampling and sample size calculation.
Zerin Jannat (18462282), Hemel Das (14555093), Tasnuva Wahed (3900745), Md. Wazed Ali (9625451), Md. Nurul Alam (18462285), Md. Jasim Uddin (9625454)   +5 more
core   +1 more source

Sample Size Calculation [PDF]

, 2020
openaire   +2 more sources

Randomized Phase II Cancer Clinical Trials to Validate Predictive Biomarkers

Biomedicines
Objectives: The design of cancer clinical trials incorporating biomarkers depends on various factors, including the trial phase, the type of biomarker and whether its role has been validated.
Baoshan Zhang, Jong-Mu Sun, Myung-Ju Ahn, Sin-Ho Jung   +3 more
doaj   +1 more source